Anti-inflammatory lanostane-type triterpene acids from Piptoporus betulinus

被引：57

作者：

Kamo, T ^{[1
]}

Asanoma, M ^{[1
]}

Shibata, H ^{[1
]}

Hirota, M ^{[1
]}

机构：

[1] Shinshu Univ, Fac Agr, Dept Biosci & Biotechnol, Nagano 3994598, Japan

来源：

JOURNAL OF NATURAL PRODUCTS | 2003年 / 66卷 / 08期

关键词：

D O I：

10.1021/np0300479

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Six lanostane-type triterpene acids were isolated from the fruiting bodies of Piptoporus betulinus. They were identified as polyporenic acids A (1) and C (2), three derivatives of polyporenic acid A (3-5), and a novel compound, (+)-12alpha,28-dihydroxy-3alpha-(3'-hydroxy-3'-methylglutaryloxy)-24-methyllanosta-8,24(31)dien-26-oic acid (6). All these compounds suppressed the 12-O-tetradecanoylphorbol-13-acetate (TPA)induced edema on mouse ears by 49-86% with a 400 nmol/ear application.

引用

页码：1104 / 1106

页数：3

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