Proinflammatory Cytokines and Skin Wound Healing in Mice

被引：81

作者：

Nosenko, M. A. ^{[1
,2
]}

Ambaryan, S. G. ^{[1
,2
]}

Drutskaya, M. S. ^{[1
]}

机构：

[1] Russian Acad Sci, Engelhardt Inst Mol Biol, Moscow 119991, Russia

[2] Moscow MV Lomonosov State Univ, Biol Fac, Immunol Dept, Moscow 119234, Russia

来源：

MOLECULAR BIOLOGY | 2019年 / 53卷 / 05期

基金：

俄罗斯基础研究基金会; 俄罗斯科学基金会;

关键词：

inflammation; regeneration; mouse models; TNF; IL-6; IL-1; interferons; NF-KAPPA-B; IL-1; RECEPTOR; IN-VIVO; EPIDERMAL-KERATINOCYTES; ESSENTIAL INVOLVEMENT; DERMAL FIBROBLASTS; INTERFERON-GAMMA; IFN-GAMMA; TGF-BETA; TNF;

D O I：

10.1134/S0026893319050121

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Skin wound healing is subject to an intricate regulation, involves many cell populations and molecular mediators, and is one of the key mechanisms that ensures the barrier functions of the skin and the maintenance of body homeostasis. The efficiency of this process is largely determined by the balance of proinflammatory and proregenerative signals, which are mediated by cytokines. The review summarizes the latest data on the role of proinflammatory cytokines, mainly tumor necrosis factor (TNF), interleukin 6 (IL-6), interleukin 1 (IL-1), and interferons (IFNs), in skin wound healing, including those obtained with the use of genome editing techniques and methods of reverse genetics to establish relevant animal models. The roles that proinflammatory cytokines play at various stages of skin regeneration are discussed for both normal state and systemic pathologies, such as diabetes. Promising approaches to treating poorly healing wounds are summarized.

引用

页码：653 / 664

页数：12

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