Evolving Techniques in Peripheral Nerve Regeneration

被引：24

作者：

Lanier, Steven T. ^{[1
]}

Hill, J. Ryan ^{[1
]}

Dy, Christopher J. ^{[1
,2
]}

Brogan, David M. ^{[1
]}

机构：

[1] Washington Univ, Dept Orthopaed Surg, 425 S Eudid Ave,Campus Box 8233, St Louis, MO 63110 USA

[2] Washington Univ, Dept Surg, Div Publ Hlth Sci, St Louis, MO 63110 USA

来源：

JOURNAL OF HAND SURGERY-AMERICAN VOLUME | 2021年 / 46卷 / 08期

关键词：

Electrical stimulation; nerve regeneration; peripheral nerve; SARM-1; ELECTRICAL-STIMULATION PROMOTES; POLYETHYLENE-GLYCOL; SCHWANN-CELLS; THERAPY; SARM1; MECHANISMS; STRATEGIES; INJECTION; RECOVERY; REPAIR;

D O I：

10.1016/j.jhsa.2021.04.019

中图分类号：

R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];

学科分类号：

摘要：

Reliable and robust peripheral nerve regeneration after a nerve injury and repair remains an elusive goal. A variety of strategies have been proposed to mitigate the effects of Wallerian degeneration (through molecular therapies), enhance axonal regeneration across the repair site (through electrical stimulation and gene therapy), and explore alternatives to suture coaptation (through the fusion of transected ends). Although most of these techniques are in their infancy, animal data and some clinical trials have demonstrated promise for improving the restoration of function after these devastating injuries. Copyright (C) 2021 by the American Society for Surgery of the Hand. All rights reserved.

引用

页码：695 / 702

页数：8

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