Comparison of rifabutin susceptibility and rpoB mutations in multi-drug-resistant Mycobacterium tuberculosis strains by DNA sequencing and the line probe assay

被引：18

作者：

Yoshida, Shiomi ^{[1
]}

Suzuki, Katsuhiro ^{[1
]}

Iwamoto, Tomotada ^{[3
]}

Tsuyuguchi, Kazunari ^{[1
]}

Tomita, Motohisa ^{[2
]}

Okada, Masaji ^{[1
]}

Sakatani, Mitsunori ^{[4
]}

机构：

[1] Natl Hosp Org, Clin Res Ctr, Kinki Chuo Chest Med Ctr, Sakai, Osaka 5918555, Japan

[2] Natl Hosp Org, Dept Clin Microbiol, Kinki Chuo Chest Med Ctr, Sakai, Osaka 5918555, Japan

[3] Kobe Inst Hlth, Dept Microbiol, Chuo Ku, Kobe, Hyogo 6500046, Japan

[4] Natl Hosp Org, Dept Resp Med, Kinki Chuo Chest Med Ctr, Kita Ku, Sakai, Osaka 5918555, Japan

来源：

JOURNAL OF INFECTION AND CHEMOTHERAPY | 2010年 / 16卷 / 05期

关键词：

Tuberculosis; Drug resistance; Rifabutin; rpoB; Line probe assay; RIFAMYCIN CROSS-RESISTANCE; IN-VITRO ACTIVITY; RIFAMPICIN; COMPLEX;

D O I：

10.1007/s10156-010-0057-5

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

We compared rifabutin susceptibility and rpoB mutations in 98 multi-drug-resistant strains of Mycobacterium tuberculosis (MDR-TB) by DNA sequencing and with a line probe assay using the commercially available INNO-LiPA Rif. TB kit (the LiPA). Our results indicated that rifabutin continues to remain active against MDR-TB strains harboring certain genetic alterations and also that the LiPA might be useful in identifying MDR-TB strains susceptible to rifabutin.

引用

页码：360 / 363

页数：4

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