A Facile Three-Component Catalyst-Free Strategy: Synthesis of Indeno[1,2-b][1,6]naphthyridine-1,10(2H)-dione Derivatives in Water

被引：2
作者：
Li, Chunmei [1 ,2 ]
Zhang, Furen [2 ]
Li, Tianci [1 ]
Liu, Zhiyuan [1 ]
Shen, Zhenlu [1 ]
机构：
[1] Zhejiang Univ Technol, Coll Chem Engn, Hangzhou 310014, Peoples R China
[2] Shaoxing Univ, Zhejiang Key Lab Alternat Technol Fine Chem Proc, Sch Chem & Chem Engn, Shaoxing 312000, Peoples R China
来源：
ASIAN JOURNAL OF ORGANIC CHEMISTRY | 2022年 / 11卷 / 06期
基金：
中国国家自然科学基金;
关键词：
catalyst-free; domino reaction; 1H-indene-1; 3(2H)-dione; 1; 6-naphthyridine; synthesis; MULTICOMPONENT REACTIONS; SOLID ACID; ONE-POT; DIASTEREOSELECTIVE SYNTHESIS; CHEMISTRY; EFFICIENT; IDENTIFICATION; HETEROCYCLES; INHIBITOR;
D O I：
10.1002/ajoc.202200145
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A catalyst-free protocol for synthesizing a new series of indeno[1,2-b][1,6]naphthyridine-1,10(2H)-dione derivatives with good to excellent yields was established based on microwave-assisted domino reaction of 4-aminopyridin-2(1H)-ones, aldehydes and 1H-indene-1,3(2H)-dione in water. The present approach exhibited useful and green features, such as water as reaction solvent, catalyst- and additive- free, short reaction time (20-30 min), as well as ease of desired products separation and purification without the need for column chromatography. Also to note, up to four new bonds were formed accompanied by generating water as sole by-product in this one-pot procedure.
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页数：5
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