Clinical Efficacy of Highly Purified hMG versus Recombinant FSH in IVF/ICSI Cycles: A Meta-Analysis

被引：15
作者：
Jee, Byung Chul [1 ,2 ]
Suh, Chang Suk [1 ,2 ,3 ]
Kim, Yong Beom [1 ]
Kim, Seok Hyun [2 ,3 ]
Moon, Shin Yong [2 ,3 ]
机构：
[1] Seoul Natl Univ, Bundang Hosp, Dept Obstet & Gynecol, Songnam 463707, Gyeonggi, South Korea
[2] Seoul Natl Univ, Coll Med, Dept Obstet & Gynecol, Seoul, South Korea
[3] Seoul Natl Univ, Med Res Ctr, Inst Reprod Med & Populat, Seoul, South Korea
来源：
GYNECOLOGIC AND OBSTETRIC INVESTIGATION | 2010年 / 70卷 / 02期
关键词：
Highly purified hMG; Recombinant FSH; IVF; Pregnancy rate; Meta-analysis; FOLLICLE-STIMULATING-HORMONE; IN-VITRO FERTILIZATION; HUMAN MENOPAUSAL GONADOTROPIN; SPERM INJECTION CYCLES; OVARIAN STIMULATION; ECONOMIC-EVALUATION; ASSISTED REPRODUCTION; CONTROLLED-TRIAL; IVF CYCLES; HP-HMG;
D O I：
10.1159/000308458
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
Background/Aims: To compare the effectiveness of highly purified hMG (Menopur) with recombinant FSH (Gonal-F) in IVF/ICSI patients who underwent ovarian hyperstimulation with pituitary suppression. Methods: A literature search of the National Library of Medicine and the National Institutes of Health (PubMed), Medline and Cochrane Controlled Trials Register was performed using the key words 'highly purified hMG' and 'recombinant FSH.' Only prospective randomized controlled trials were included when they compared IVF/ICSI outcomes after administration of Menopur versus Gonal-F. Five studies met the inclusion criteria and were reviewed. The primary outcome measure was ongoing pregnancy/live birth. Results: Ongoing pregnancy rate per started cycle (RR: 1.10, 95% CI: 0.96-1.26) or per embryo transfer (RR: 1.13, 95% CI: 0.99-1.29), as well as live birth rate per embryo transfer (RR: 1.14, 95% CI: 0.98-1.33), is similar between the Menopur and the Gonal-F group. Conclusion: The combined data presented in this meta-analysis do not support a clinical superiority of Gonal-F over Menopur. Copyright (C) 2010 S. Karger AG, Basel
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页码：132 / 137
页数：6
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