Ferrocenoyl-amino acids: redox response towards di- and trivalent metal ions

被引:25
|
作者
Appoh, FE [1 ]
Sutherland, TC [1 ]
Kraatz, HB [1 ]
机构
[1] Univ Saskatchewan, Dept Chem, Saskatoon, SK S7N 5C9, Canada
基金
加拿大创新基金会; 加拿大自然科学与工程研究理事会;
关键词
ferrocene; amino acid; bioconjugate; metal binding; electrochemistry;
D O I
10.1016/j.jorganchem.2004.11.027
中图分类号
O61 [无机化学];
学科分类号
070301 ; 081704 ;
摘要
The interaction of six ferrocene-amino acid conjugates (Fc-CO-Gly-OH (2a), Fc-CO-Asp-OH (3a), Fc-CO-Glu-OH (4a), 1,1'-Fc(CO-Gly-OH) (2b), 1,1'-Fc(CO-Asp-OH) (3b), and 1,1'-Fc(CO-Glu-OH) (4b)) with Mg2+ Ca2+, Zn2+, La3+, and Tb3+ was investigated in aqueous solutions using cyclic voltammetry (CV) and differential pulse voltammetry (DPV). Addition of metal ions to solutions caused, in some cases, large changes in the half-wave potential, E-1/2. Our electrochemical results show that the Gly systems, 2a and 2b, show a preference for binding Mg2+, whereas the Asp and Glu conjugates prefer binding Ln(3+). (c) 2004 Elsevier B.V. All rights reserved.
引用
收藏
页码:1209 / 1217
页数:9
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