Lethal photosensitisation of Staphylococcus aureus using a toluidine blue O-tiopronin-gold nanoparticle conjugate

被引：86
作者：
Gil-Tomas, Jesus
Tubby, Sarah
Parkin, Ivan P.
Narband, Naima
Dekker, Linda
Nair, Sean P.
Wilson, Michael
Street, Cale
机构：
[1] UCL, Dept Chem, London WC1H 0AJ, England
[2] UCL, Eastman Dent Inst, Div Microbial Dis, London WC1X 8LD, England
[3] Ondine Biopharm Corp, Redmond, WA 98052 USA
来源：
JOURNAL OF MATERIALS CHEMISTRY | 2007年 / 17卷 / 35期
关键词：
D O I：
10.1039/b706615e
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
Covalently coupling toluidine blue O-tiopronin to a gold nanoparticle forms an enhanced, exceptionally potent antimicrobial agent when activated by white light or 632 nm laser light. Aqueous solutions of tiopronin-gold nanoparticles had no antimicrobial effect and, when added to solutions of toluidine blue O, did not enhance the antimicrobial effect of the latter. The minimum bactericidal concentration of the covalently coupled toluidine blue O-tiopronin gold conjugate for Staphylococcus aureus was at least four times lower than that of free toluidine blue O.
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页码：3739 / 3746
页数：8
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