Stimuli-responsive magnetic nanoparticles for tumor-targeted bimodal imaging and photodynamic/hyperthermia combination therapy

被引：48

作者：

Kim, Kyoung Sub ^{[1
]}

Kim, Jiyoung ^{[1
]}

Lee, Joo Young ^{[1
]}

Matsuda, Shofu ^{[2
]}

Hideshima, Sho ^{[3
]}

Mori, Yasurou ^{[4
]}

Osaka, Tetsuya ^{[2
,3
]}

Na, Kun ^{[1
]}

机构：

[1] Catholic Univ Korea, Dept Biotechnol, 43 Jibong Ro, Bucheon Si 420743, Gyeonggi Do, South Korea

[2] Waseda Univ, Grad Sch Adv Sci & Engn, Shinjuku Ku, 3-4-1 Okubo, Tokyo 1698555, Japan

[3] Waseda Univ, Res Org Nano & Life Innovat, Shinjuku Ku, 513 Wasedatsurumaki Cho, Tokyo 1620041, Japan

[4] Catholic Univ Korea, CUK WASEDA Ctr Nanotech Res, 43 Jibong Ro, Bucheon Si 420743, Gyeonggi Do, South Korea

来源：

NANOSCALE | 2016年 / 8卷 / 22期

关键词：

IRON-OXIDE NANOPARTICLES; PHOTODYNAMIC THERAPY; HYALURONIC-ACID; BREAST-CANCER; FE3O4; NANOPARTICLES; HYPERTHERMIA; CELLS; INTERNALIZATION; NEOPLASIA; NANOGELS;

D O I：

10.1039/c6nr02273a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Despite magnetic nanoparticles having shown great potential in cancer treatment, tremendous challenges related to diagnostic sensitivity and treatment efficacy for clinical application remain. Herein, we designed optimized multifunctional magnetite nanoparticles (AHP@MNPs), composed of Fe3O4 nanoparticles and photosensitizer conjugated hyaluronic acid (AHP), to achieve enhanced tumor diagnosis and therapy. Fe3O4 nanoparticles (MNPs) were synthesized by a facile hydrolysis method. MNPs have higher biocompatibility, controllable particle sizes, and desirable magnetic properties. The fabricated AHP@MNPs have enhanced water solubility (average size: 108.13 +/- 1.08 nm), heat generation properties, and singlet oxygen generation properties upon magnetic and laser irradiation. The AHP@MNPs can target tumors via CD44 receptor-mediated endocytosis, which have enhanced tumor therapeutic effects through photodynamic/hyperthermia-combined treatment without any drugs. We successfully detected tumors implanted in mice via magnetic resonance imaging and optical imaging. Furthermore, we demonstrated the photodynamic/hyperthermia-combined therapeutic efficacy of AHP@MNPs with synergistically enhanced efficacy against cancer.

引用

页码：11625 / 11634

页数：10

共 43 条

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