Isolevuglandin-protein adducts in oxidized low density lipoprotein and human plasma: A strong connection with cardiovascular disease

被引：24

作者：

Salomon, RG ^{[1
]}

Kaur, K ^{[1
]}

Batyreva, E ^{[1
]}

机构：

[1] Case Western Reserve Univ, Dept Chem, Cleveland, OH 44106 USA

来源：

TRENDS IN CARDIOVASCULAR MEDICINE | 2000年 / 10卷 / 02期

关键词：

D O I：

10.1016/S1050-1738(00)00040-2

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Isolevuglandins (isoLGs) are extremely reactive gamma -ketoaldehydes that avidly bind covalently with proteins and cause protein-protein as well as DNA-protein crosslinking. IsoLG-protein adducts are generated upon oxidation of low-density lipoprotein (LDL), and may contribute to atherogenesis since such adducts cause recognition and endocytosis of the modified LDL by macrophage cells. Levels of isoLG-protein adducts in human blood plasma are more closely correlated with disease than are the classical risk factors LDL or total cholesterol. We review the basic research that eventuated in the discovery of isoLGs and describe what is known about their natural occurrence and close connection with cardiovascular disease. (Trends Cardiovasc Med 2000:10:53-59). (C) 2000, Elsevier Science Inc.

引用

页码：53 / 59

页数：7

共 38 条

[1] INTERMEDIATES IN THE PAAL-KNORR SYNTHESIS OF PYRROLES 4-OXOALDEHYDES [J].

AMARNATH, V ;

AMARNATH, K ;

VALENTINE, WM ;

ENG, MA ;

GRAHAM, DG .

CHEMICAL RESEARCH IN TOXICOLOGY, 1995, 8 (02) :234-238

[2] STUDIES ON THE COVALENT BINDING OF AN INTERMEDIATE(S) IN PROSTAGLANDIN BIOSYNTHESIS TO TISSUE MACROMOLECULES [J].

ANDERSON, MW ;

CRUTCHLEY, DJ ;

CHAUDHARI, A ;

WILSON, AGE ;

ELING, TE .

BIOCHIMICA ET BIOPHYSICA ACTA, 1979, 573 (01) :40-50

[3] Radioimmunoassay of 8-iso-prostaglandin F2α:: an index for oxidative injury via free radical catalysed lipid peroxidation [J].

Basu, S .

PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS, 1998, 58 (04) :319-325

[4] MYOCARDIAL STUNNING IN MAN [J].

BOLLI, R .

CIRCULATION, 1992, 86 (06) :1671-1691

[5] Characterization of the lysyl adducts formed from prostaglandin H2 via the levuglandin pathway [J].

Boutaud, O ;

Brame, CJ ;

Salomon, RG ;

Roberts, LJ ;

Oates, JA .

BIOCHEMISTRY, 1999, 38 (29) :9389-9396

[6] Identification of extremely reactive γ-ketoaldehydes (isolevuglandins) as products of the isoprostane pathway and characterization of their lysyl protein adducts [J].

Brame, CJ ;

Salomon, RG ;

Morrow, JD ;

Roberts, LJ .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (19) :13139-13146

[7] 8-Epi PGF(2 alpha) generation during coronary reperfusion - A potential quantitative marker of oxidant stress in vivo [J].

Delanty, N ;

Reilly, MP ;

Pratico, D ;

Lawson, JA ;

McCarthy, JF ;

Wood, AE ;

Ohnishi, ST ;

Fitzgerald, DJ ;

FitzGerald, GA .

CIRCULATION, 1997, 95 (11) :2492-2499

[8] FORMATION AND STABILITY OF PYRROLE ADDUCTS IN THE REACTION OF LEVUGLANDIN E(2) WITH PROTEINS [J].

DIFRANCO, E ;

SUBBANAGOUNDER, G ;

KIM, S ;

MURTHI, K ;

TANEDA, S ;

MONNIER, VM ;

SALOMON, RG .

CHEMICAL RESEARCH IN TOXICOLOGY, 1995, 8 (01) :61-67

[9] COVALENT BINDING OF AN INTERMEDIATE(S) IN PROSTAGLANDIN BIOSYNTHESIS TO GUINEA-PIG LUNG MICROSOMAL PROTEIN [J].

ELING, TE ;

WILSON, AGE ;

CHAUDHARI, A ;

ANDERSON, MW .

LIFE SCIENCES, 1977, 21 (02) :245-251

[10] QUANTITATIVE-DETERMINATION OF PROSTAGLANDINS AND MALONDIALDEHYDE FORMED BY ARACHIDONATE OXYGENASE (PROSTAGLANDIN SYNTHETASE) SYSTEM OF BOVINE SEMINAL VESICLE [J].

FLOWER, RJ ;

CUSHMAN, DW ;

CHEUNG, HS .

PROSTAGLANDINS, 1973, 4 (03) :325-341

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