Synthetic strategies for preparation of cyclen-based MRI contrast agents

被引：33

作者：

Cakic, Nevenka ^{[1
]}

Guenduez, Serhat ^{[1
]}

Rengarasu, Rathikrishnan ^{[1
]}

Angelovski, Goran ^{[1
]}

机构：

[1] Max Planck Inst Biol Cybernet, MR Neuroimaging Agents Grp, D-72076 Tubingen, Germany

来源：

TETRAHEDRON LETTERS | 2015年 / 56卷 / 06期

关键词：

Cyclen; Macrocyclic ligands; Magnetic resonance imaging; Lanthanide complexes; BIFUNCTIONAL CHELATING-AGENT; MAGNETIC-RESONANCE; LANTHANIDE COMPLEXES; REGIOSELECTIVE SYNTHESIS; N-FUNCTIONALIZATION; ACID; DERIVATIVES; PEPTIDE; ROUTE;

D O I：

10.1016/j.tetlet.2014.12.087

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Cyclen-based macrocyclic ligands have an essential role in the development of contrast agents for magnetic resonance imaging (MRI). A prevailing need for preparation of multifunctional probes triggered a number of attempts to synthesize and derivatize ligands which efficiently chelate lanthanide ions and have advantageous MRI properties. This digest Letter summarizes the most common synthetic approaches for the preparation of macrocyclic ligands based on cyclen depending on the desired application. (C) 2014 Published by Elsevier Ltd.

引用

页码：759 / 765

页数：7

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