Analysis of TGCA data reveals genetic and epigenetic changes and biological function of MUC family genes in colorectal cancer

被引：12
|
作者：
Jiang, Zhipeng [1 ,2 ]
Wang, Huashe [1 ,2 ]
Li, Liang [1 ]
Hou, Zehui [1 ,2 ]
Liu, Wei [1 ,2 ]
Zhou, Taicheng [1 ,2 ]
Li, Yingru [1 ,2 ]
Chen, Shuang [1 ,2 ]
机构：
[1] Sun Yat Sen Univ, Affiliated Hosp 6, Dept Gastrointestinal Surg, 26 Yuancunerheng Rd, Guangzhou 510655, Guangdong, Peoples R China
[2] Guangdong Inst Gastroenterol, Guangdong Prov Key Lab Colorectal & Pelv Floor Di, Natl Key Clin Discipline, Guangzhou 510655, Guangdong, Peoples R China
来源：
FUTURE ONCOLOGY | 2019年 / 15卷 / 35期
关键词：
colorectal cancer; epigenetic; genetic; MUC; TCGA; RISK-FACTORS; EXPRESSION; METHYLATION; MUTATION; PATHWAY; CELLS; RED;
D O I：
10.2217/fon-2019-0363
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Aim: Few studies focused on functions and regulatory networks of MUC family members in colorectal cancer based on comprehensive analysis of online database. Materials & methods: Copy number variation, methylation, pathway analysis and drug influence on MUC expression were analyzed based on The Cancer Genome Atlas and GTEx database. Results: Copy number variation analysis showed MUC heterozygous amplification and heterozygous deletion predominate. Methylation of MUC17, MUC12 and MUC4 were found related to gene expression. Function of MUC family genes mainly affects pathways such as apoptosis, cell cycle, DNA damage and EMT pathways. PLX4720, dabrafenib, gefitinib, afatinib and austocystin D can alter the expression of MUC gene. Conclusion: The genetic and epigenetic changes of MUC are related to the level of MUC expression in colorectal cancer.
引用
收藏
页码：4031 / 4043
页数：13
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