Analysis of TGCA data reveals genetic and epigenetic changes and biological function of MUC family genes in colorectal cancer

被引：12
|
作者：
Jiang, Zhipeng [1 ,2 ]
Wang, Huashe [1 ,2 ]
Li, Liang [1 ]
Hou, Zehui [1 ,2 ]
Liu, Wei [1 ,2 ]
Zhou, Taicheng [1 ,2 ]
Li, Yingru [1 ,2 ]
Chen, Shuang [1 ,2 ]
机构：
[1] Sun Yat Sen Univ, Affiliated Hosp 6, Dept Gastrointestinal Surg, 26 Yuancunerheng Rd, Guangzhou 510655, Guangdong, Peoples R China
[2] Guangdong Inst Gastroenterol, Guangdong Prov Key Lab Colorectal & Pelv Floor Di, Natl Key Clin Discipline, Guangzhou 510655, Guangdong, Peoples R China
来源：
FUTURE ONCOLOGY | 2019年 / 15卷 / 35期
关键词：
colorectal cancer; epigenetic; genetic; MUC; TCGA; RISK-FACTORS; EXPRESSION; METHYLATION; MUTATION; PATHWAY; CELLS; RED;
D O I：
10.2217/fon-2019-0363
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Aim: Few studies focused on functions and regulatory networks of MUC family members in colorectal cancer based on comprehensive analysis of online database. Materials & methods: Copy number variation, methylation, pathway analysis and drug influence on MUC expression were analyzed based on The Cancer Genome Atlas and GTEx database. Results: Copy number variation analysis showed MUC heterozygous amplification and heterozygous deletion predominate. Methylation of MUC17, MUC12 and MUC4 were found related to gene expression. Function of MUC family genes mainly affects pathways such as apoptosis, cell cycle, DNA damage and EMT pathways. PLX4720, dabrafenib, gefitinib, afatinib and austocystin D can alter the expression of MUC gene. Conclusion: The genetic and epigenetic changes of MUC are related to the level of MUC expression in colorectal cancer.
引用
收藏
页码：4031 / 4043
页数：13
相关论文
共 50 条
  • [21] Epigenomic Analysis of Aberrantly Methylated Genes in Colorectal Cancer Identifies Genes Commonly Affected by Epigenetic Alterations
    Kim, Young-Ho
    Lee, Han Cheol
    Kim, Seon-Young
    Yeom, Young Il
    Ryu, Kyung Ju
    Min, Byung-Hoon
    Kim, Duk-Hwan
    Son, Hee Jung
    Rhee, Poong-Lyul
    Kim, Jae J.
    Rhee, Jong Chul
    Kim, Hee Cheol
    Chun, Ho-Kyung
    Grady, William M.
    Kim, Yong Sung
    ANNALS OF SURGICAL ONCOLOGY, 2011, 18 (08) : 2338 - 2347
  • [22] RNA Sequencing and Bioinformatics Analysis Reveals the Downregulation of DNA Replication Genes by Morindone in Colorectal Cancer Cells
    Chee, Cheok Wui
    Hashim, Najihah Mohd
    Abdullah, Iskandar
    Rashid, Nurshamimi Nor
    APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY, 2024, 196 (06) : 3216 - 3233
  • [23] A Systematic Pan-Cancer Analysis of Genetic Heterogeneity Reveals Associations with Epigenetic Modifiers
    de Matos, Mafalda Ramos
    Posa, Ioana
    Carvalho, Filipa Sofia
    Morais, Vanessa Alexandra
    Grosso, Ana Rita
    de Almeida, Sergio Fernandes
    CANCERS, 2019, 11 (03)
  • [24] Genetic analysis of Caveolin-1 and eNOS genes in colorectal cancer
    Chaves Conde, Manuel
    Ramirez-Lorca, Reposo
    Miguel Esteban Lopez-Jamar, Jose
    Molero, Eva
    Andres Ramirez-Armengol, Juan
    Andres Moreno Nogueira, Jose
    Hidalgo Pascual, Manuel
    Ruiz, Agustin
    Garcia Martin-Cordovas, Carlos
    Miguel Real, Luis
    Luis Royo, Jose
    ONCOLOGY REPORTS, 2006, 16 (02) : 353 - 359
  • [25] Integrative analysis reveals early and distinct genetic and epigenetic changes in intraductal papillary and tubulopapillary cholangiocarcinogenesis
    Goeppert, Benjamin
    Stichel, Damian
    Toth, Reka
    Fritzsche, Sarah
    Loeffler, Moritz Anton
    Schlitter, Anna Melissa
    Neumann, Olaf
    Assenov, Yassen
    Vogel, Monika Nadja
    Mehrabi, Arianeb
    Hoffmann, Katrin
    Koehler, Bruno
    Springfeld, Christoph
    Weichenhan, Dieter
    Plass, Christoph
    Esposito, Irene
    Schirmacher, Peter
    von Deimling, Andreas
    Roessler, Stephanie
    GUT, 2022, 71 (02) : 391 - 401
  • [26] A comprehensive analysis of common genetic variation in MUC1, MUC5AC, MUC6 genes and risk of stomach cancer
    Jia, Yanbin
    Persson, Christina
    Hou, Lifang
    Zheng, Zongli
    Yeager, Meredith
    Lissowska, Jolanta
    Chanock, Stephen J.
    Chow, Wong-Ho
    Ye, Weimin
    CANCER CAUSES & CONTROL, 2010, 21 (02) : 313 - 321
  • [27] Pan-cancer analysis of m5C regulator genes reveals consistent epigenetic landscape changes in multiple cancers
    He, Yuting
    Yu, Xiao
    Zhang, Menggang
    Guo, Wenzhi
    WORLD JOURNAL OF SURGICAL ONCOLOGY, 2021, 19 (01)
  • [28] Glycan analysis of colorectal cancer samples reveals stage-dependent changes in CEA glycosylation patterns
    Zhao, Qianqian
    Zhan, Tiancheng
    Deng, Zaian
    Li, Qianqian
    Liu, Yaming
    Yang, Shaojie
    Ji, Dengbo
    Li, Yan
    CLINICAL PROTEOMICS, 2018, 15
  • [29] Integrative analysis of the immunological significances of guanylate binding protein family genes in microsatellite stability colorectal cancer
    Wang, Xin
    Han, Ting
    Wang, Yinchun
    Yang, Rui
    Yang, Qingqiang
    Li, Jianxin
    HELIYON, 2024, 10 (18)
  • [30] BRCA genes as candidates for colorectal cancer genetic testing panel: systematic review and meta-analysis
    Zhewen Feng
    Xiaobao Yang
    Mingwei Tian
    Na Zeng
    Zhigang Bai
    Wei Deng
    Yanyan Zhao
    Jianru Guo
    Yingchi Yang
    Zhongtao Zhang
    Yun Yang
    BMC Cancer, 23
12345