An investigation of the influence of process and formulation variables on mechanical properties of high shear granules using design of experiment

被引：29
作者：
Mangwandi, Chirangano [1 ]
Adams, Michael J. [2 ]
Hounslow, Michael J. [1 ]
Salman, Agba D. [1 ]
机构：
[1] Univ Sheffield, Dept Chem & Biol Engn, Particle Prod Grp, Sheffield S1 3JD, S Yorkshire, England
[2] Univ Birmingham, Sch Chem Engn, Birmingham B15 2TT, W Midlands, England
来源：
INTERNATIONAL JOURNAL OF PHARMACEUTICS | 2012年 / 427卷 / 02期
关键词：
Granulation; Strength; Packing coefficient; Experimental design; Elastoplastic ratio; COMPRESSIBLE PARACETAMOL; COMPACTION PROPERTIES; MELT PELLETIZATION; WET GRANULATION; PARTICLE-SIZE; FUNCTIONALITY; OPTIMIZATION; PARAMETERS; BEHAVIOR; MIXTURE;
D O I：
10.1016/j.ijpharm.2012.02.029
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Being able to predict the properties of granules from the knowledge of the process and formulation variables is what most industries are striving for. This research uses experimental design to investigate the effect of process variables and formulation variables on mechanical properties of pharmaceutical granules manufactured from a classical blend of lactose and starch using hydroxypropyl cellulose (HPC) as the binder. The process parameters investigated were granulation time and impeller speed whilst the formulation variables were starch-to-lactose ratio and HPC concentration. The granule properties investigated include granule packing coefficient and granule strength. The effect of some components of the formulation on mechanical properties would also depend on the process variables used in granulation process. This implies that by subjecting the same formulation to different process conditions results in products with different properties. (C) 2012 Elsevier B.V. All rights reserved.
引用
收藏
页码：328 / 336
页数：9
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