4-nor-β-Patchoulene sesquiterpenoids from the essential oil of Pogostemon cablin

被引：21

作者：

Liu, Jian-lin ^{[1
,2
]}

Li, Xiao-hong ^{[1
,2
]}

Peng, Cheng ^{[1
,2
]}

Lin, Da-sheng ^{[2
,3
]}

Wang, Ya-nan ^{[4
,5
]}

Yang, Yu-ting ^{[1
,2
]}

Zhou, Qin-mei ^{[1
,2
]}

Xiong, Liang ^{[1
,2
]}

机构：

[1] Sichuan Prov & Minist Sci & Technol, State Key Lab Breeding Base Systemat Res Dev & Ut, Chengdu 611137, Peoples R China

[2] Chengdu Univ Tradit Chinese Med, Coll Pharm, Chengdu 611137, Peoples R China

[3] Chengdu Huasun Grp Inc Ltd, Chengdu 610075, Peoples R China

[4] Chinese Acad Med Sci, Inst Mat Med, State Key Lab Bioact Subst & Funct Nat Med, Beijing 100050, Peoples R China

[5] Peking Union Med Coll, Beijing 100050, Peoples R China

来源：

PHYTOCHEMISTRY LETTERS | 2015年 / 12卷

关键词：

Pogostemon cablin; Essential oil; Sesquiterpenoids; nor-beta-Patchoulenes; Cytotoxic activities;

D O I：

10.1016/j.phytol.2015.02.016

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Four nor-beta-patchoulene sesquiterpenoids including three new compounds (1-3) and a new natural product (4) were isolated from the essential oil of the leaves and stems of Pogostemon cablin. Their structures were elucidated by detailed spectroscopic analysis, using 1D- and 2D-NMR techniques. This is the first report of 4-nor-beta-patchoulenes from plants. All isolates were evaluated for the cytotoxic activities on human cancer cells in vitro. Compound 3 showed weak cytotoxic activities against NCI-H1975 and HePG-2 with IC50 values of 49.9 mu g/mL and 56.0 mu g/mL, respectively. (C) 2015 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.

引用

页码：27 / 30

页数：4

共 16 条

[1] SYNTHESIS OF PATCHOULI ALCOHOL [J].