Wnt signaling in somite development

被引:18
作者
Geetha-Loganathan, Poongodi [1 ]
Nimmagadda, Suresh [1 ]
Scaal, Martin [1 ]
Huang, Ruijin [1 ]
Christ, Bodo [1 ]
机构
[1] Univ Freiburg, Inst Anat & Cell Biol, Dept Mol Embryol, D-79104 Freiburg, Germany
关键词
Wnts; somite formation; patterning; differentiation;
D O I
10.1016/j.aanat.2007.12.003
中图分类号
R602 [外科病理学、解剖学]; R32 [人体形态学];
学科分类号
100101 ;
摘要
During vertebrate embryogenesis, specialized mesodermal, structures, called somites, give rise to a variety of mesodermal. tissues including skeletal. muscles, vertebrae and dermis. Development of the somites is a rhythmic process that involves a series of steps including segmentation of the paraxial mesoderm, epithelialization, somite formation, somite maturation, somite patterning and differentiation of somitic cells into different lineages. Wnt signaling has been found to play crucial. roles in multiple steps of somite development. In this review, we present a brief overview of current knowledge on Wnt signaling events during the development of somites and their derivatives. (C) 2008 Elsevier GnnbH. All rights reserved.
引用
收藏
页码:208 / 222
页数:15
相关论文
共 141 条
[1]   WNT signals are required for the initiation of hair follicle development [J].
Andl, T ;
Reddy, ST ;
Gaddapara, T ;
Millar, SE .
DEVELOPMENTAL CELL, 2002, 2 (05) :643-653
[2]  
AOYAMA H, 1988, DEVELOPMENT, V104, P15
[3]   β-catenin activation is necessary and sufficient to specify the dorsal dermal fate in the mouse [J].
Atit, Radhika ;
Sgaier, Sema K. ;
Mohamed, Othman A. ;
Taketo, Makoto M. ;
Dufort, Daniel ;
Joyner, Alexandra L. ;
Niswander, Lee ;
Conlon, Ronald A. .
DEVELOPMENTAL BIOLOGY, 2006, 296 (01) :164-176
[4]   Segmentation in vertebrates: clock and gradient finally joined [J].
Aulehla, A ;
Herrmann, BG .
GENES & DEVELOPMENT, 2004, 18 (17) :2060-2067
[5]   Wnt3A plays a major role in the segmentation clock controlling somitogenesis [J].
Aulehla, A ;
Wehrle, C ;
Brand-Saberi, B ;
Kemler, R ;
Gossler, A ;
Kanzler, B ;
Herrmann, BG .
DEVELOPMENTAL CELL, 2003, 4 (03) :395-406
[6]   Pax genes and skeletal development [J].
Balling, R ;
Helwig, U ;
Nadeau, J ;
Neubuser, A ;
Schmahl, W ;
Imai, K .
MOLECULAR AND DEVELOPMENTAL BIOLOGY OF CARTILAGE, 1996, 785 :27-33
[7]   Cloning and characterization of chicken Paraxis: A regulator of paraxial mesoderm development and somite formation [J].
Barnes, GL ;
Alexander, PG ;
Hsu, CW ;
Mariani, BD ;
Tuan, RS .
DEVELOPMENTAL BIOLOGY, 1997, 189 (01) :95-111
[8]  
BELLAIRS R, 1978, J EMBRYOL EXP MORPH, V46, P207
[9]  
BERGEMANN AD, 1995, MOL CELL BIOL, V15, P4921
[10]   Armadillo/β-catenin signals in the nucleus -: proof beyond a reasonable doubt? [J].
Bienz, M ;
Clevers, H .
NATURE CELL BIOLOGY, 2003, 5 (03) :179-182