Oxidized LDL and anti-oxidized LDL antibodies in atherosclerosis - Novel insights and future directions in diagnosis and therapy

被引：143

作者：

Hartley, Adam ^{[1
]}

Haskard, Dorian ^{[1
]}

Khamis, Ramzi ^{[1
]}

机构：

[1] Imperial Coll London, Natl Heart & Lung Inst, Hammersmith Hosp Campus,Cane Road, London W12 0NN, England

来源：

TRENDS IN CARDIOVASCULAR MEDICINE | 2019年 / 29卷 / 01期

关键词：

Oxidized low-density lipoprotein; Atherosclerosis; Vulnerable plaque; LOW-DENSITY-LIPOPROTEIN; OXIDATION-SPECIFIC EPITOPES; APOLIPOPROTEIN B-100; IMMUNE-COMPLEXES; CARDIOVASCULAR EVENTS; IGM AUTOANTIBODIES; MDA-LDL; CORONARY; BIOMARKERS; DISEASE;

D O I：

10.1016/j.tcm.2018.05.010

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We provide an up-to-date overview of current topics surrounding oxidized low-density lipoprotein (oxLDL) and its related antibodies in the quest to better identify the individuals at risk of cardiovascular disease and atherosclerotic plaques with unfavorable characteristics. We discuss the potential of oxLDL and anti-oxLDL antibodies as serum biomarkers of cardiovascular disease and emerging studies examining the targeting of arterial oxLDL for imaging and therapeutic delivery. (C) 2018 Elsevier Inc. All rights reserved.

引用

页码：22 / 26

页数：5

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