Synthesis and Characterization of Ifosfamide Intercalated Layered Double Hydroxides

被引：9

作者：

Nie, Hong-Qian ^{[1
]}

Hou, Wan-Guo ^{[1
,2
]}

机构：

[1] Shandong Univ, Key Lab Colloid & Interface Chem, Minist Educ, Jinan 250100, Shandong, Peoples R China

[2] Qingdao Univ Sci & Technol, Coll Chem & Mol Engn, Qingdao, Shandong, Peoples R China

来源：

JOURNAL OF DISPERSION SCIENCE AND TECHNOLOGY | 2012年 / 33卷 / 1-3期

关键词：

Controlled release; ifosfamide; layered double hydroxides; nanohybrids; COMPOUND NANOHYBRIDS; CONTROLLED-RELEASE; ORGANIC-COMPOUNDS; ANIONIC CLAYS; HYDROTALCITE; NANOCOMPOSITES; DELAMINATION; ADSORPTION; FILMS; WATER;

D O I：

10.1080/01932691.2011.562446

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Two anionic surfactants, sodium dodecyl sulfate (SDS) and sodium dodecylbenzensulfonate (SDBS), were intercalated into Mg2Al layered double hydroxides (LDHs) using the anion exchange method. Then an alkylating oxazaphosphorine anticancer agent, ifosfamide (IFO), was intercalated into the surfactant-modified LDHs. The IFO-surfactant-LDHs nanohybrids were characterized by PXRD, FTIR, TEM, and elemental chemical analyses. The in vitro drug release from the nanohybrids is remarkably lower than that from the corresponding physical mixture at pH 7.5. The obtained results show these IFO-surfactant-LDHs nanohybrids can be used as potential anticancer drug controlled release system.

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页码：339 / 345

页数：7

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