Trial in Progress: A Phase II Window of Opportunity Study of the BCMAxCD3 Bispecific Antibody REGN5458 in Previously Untreated Patients with Symptomatic Multiple Myeloma

被引：2

作者：

Ferreri, Christopher J. ^{[1
]}

Quatela, Steven E. ^{[2
]}

Aina, Sean ^{[2
]}

Roy, Pourab ^{[2
]}

Boyapati, Anita ^{[2
]}

Lorenc, Karen Rodriguez ^{[2
]}

Kroog, Glenn S. ^{[2
]}

Orlowski, Robert Z. ^{[1
]}

机构：

[1] Univ Texas MD Anderson Canc Ctr, Houston, TX USA

[2] Regeneron Pharmaceut Inc, Tarrytown, NY USA

来源：

BLOOD | 2022年 / 140卷

关键词：

D O I：

10.1182/blood-2022-158396

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

引用

页码：10129 / 10130

页数：2

共 50 条

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Rodriguez Otero, Paula ;

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Leleu, Xavier ;

Manier, Salomon ;

Dimopoulos, Meletios A. ;

Victoria Mateos, Maria ;

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Bumma, Naresh ;

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Roy, Pourab ;

Lorenc, Karen Rodriguez ;

Kroog, Glenn S. ;

Sarkaria, Shawn M. .

BLOOD, 2022, 140 :4444-4446

[2] Updated Safety and Efficacy of REGN5458, a BCMAxCD3 Bispecific Antibody, Treatment for Relapsed/Refractory Multiple Myeloma: A Phase 1/2 First-in-Human Study [J].

Bumma, Naresh ;

Richter, Joshua ;

Brayer, Jason ;

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Dhodapkar, Madhav ;

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Mawad, Raya ;

Maly, Joseph J. ;

Lentzsch, Suzanne ;

Suvannasankha, Attaya ;

Roy, Pourab ;

Dey, Jyotirmoy ;

Chokshi, Dhruti ;

Boyapati, Anita ;

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Houvras, Yariv ;

Lorenc, Karen Rodriguez ;

Kroog, Glenn S. ;

Jagannath, Sundar .

BLOOD, 2022, 140 :10140-10141

[3] Early, deep, and durable responses, and low rates of cytokine release syndrome with REGN5458, a BCMAxCD3 bispecific antibody, in a Phase 1/2 study in patients with relapsed/refractory multiple myeloma [J].

Zonder, Jeffrey ;

Richter, Joshua ;

Bumma, Naresh ;

Brayer, Jason ;

Hoffman, James E. ;

Bensinger, William I. ;

Wu, Ka Lung ;

Xu, Linzhi ;

Chokshi, Dhruti ;

Boyapati, Anita ;

Cronier, Damien ;

Houvras, Yariv ;

Lorenc, Karen Rodriguez ;

Kroog, Glenn S. ;

Dhodapkar, Madhav V. ;

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Cooper, Dennis ;

Jagannath, Sundar .

CLINICAL LYMPHOMA MYELOMA & LEUKEMIA, 2022, 22 :S35-S35

[4] Early, Deep, and Durable Responses, and Low Rates of Cytokine Release Syndrome With REGN5458, a BCMAxCD3 Bispecific Antibody, in a Phase 1/2 First-In-Human Study in Patients With Relapsed/Refractory Multiple Myeloma [J].

Zonder, Jeffrey A. ;

Richter, Joshua ;

Bumma, Naresh ;

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Hoffman, James E. ;

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Wu, Ka Lung ;

Xu, Linzhi ;

Chokshi, Dhruti ;

Boyapati, Anita ;

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Houvras, Yariv ;

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Kroog, Glenn S. ;

Dhodapkar, Madhav V. ;

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Jagannath, Sundar .

CLINICAL LYMPHOMA MYELOMA & LEUKEMIA, 2022, 22 :S406-S407

[5] Early, Deep, and Durable Responses, and Low Rates of Cytokine Release Syndrome with REGN5458, a BCMAxCD3 Bispecific Monoclonal Antibody, in a Phase 1/2 First-in-Human Study in Patients with Relapsed/Refractory Multiple Myeloma (RRMM) [J].

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BLOOD, 2021, 138

[6] REGN5458, a Bispecific BCMAxCD3 T Cell Engaging Antibody, Demonstrates Robust In Vitro and In Vivo Anti-Tumor Efficacy in Multiple Myeloma Models, Comparable to That of BCMA CAR T Cells [J].

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[7] A Phase I Study of a Novel BCMAxCD3 Bispecific Antibody Emb-06 in Relapsed or Refractory Multiple Myeloma [J].

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Bao, Li ;

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Li, Chunrui ;

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Lu, Qiaoyang ;

Jiang, Chengjun ;

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Tao, Yi ;

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BLOOD, 2024, 144 :499-499

[8] Trial in progress: linvoseltamab, a BCMAxCD3 bispecific antibody, in a Phase 1b multi-cohort study of combination regimens for patients with relapsed/refractory multiple myeloma [J].

Rodriguez-Otero, Paula ;

Joseph, Nisha ;

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Lorenc, Karen Rodriguez ;

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Sarkaria, Shawn .

CLINICAL LYMPHOMA MYELOMA & LEUKEMIA, 2023, 23 :S60-S60

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BLOOD, 2019, 134

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