Longitudinal Analysis of Group A Streptococcus emm Types and emm Clusters in a High-Prevalence Setting: Relationship between Past and Future Infections

被引：13

作者：

Campbell, Patricia Therese ^{[1
,2
,3
]}

Tong, Steven Y. C. ^{[4
,5
,6
]}

Geard, Nicholas ^{[1
,2
,7
]}

Davies, Mark R. ^{[8
]}

Worthing, Kate A. ^{[8
]}

Lacey, Jake A. ^{[5
]}

Smeesters, Pierre R. ^{[3
,9
,10
,11
]}

Batzloff, Michael R. ^{[12
]}

Kado, Joseph ^{[13
,14
,15
,16
]}

Jenney, Adam W. J. ^{[11
,14
]}

Mcvernon, Jodie ^{[1
,2
,3
,17
]}

Steer, Andrew C. ^{[3
,11
,18
]}

机构：

[1] Royal Melbourne Hosp, Victorian Infect Dis Ref Lab, Peter Doherty Inst Infect & Immun, Epidemiol Unit, Melbourne, Vic, Australia

[2] Univ Melbourne, Melbourne, Vic, Australia

[3] Royal Childrens Hosp, Murdoch Childrens Res Inst, Melbourne, Vic, Australia

[4] Royal Childrens Hosp, Victorian Infect Dis Reference Lab, Epidemiol Unit, Melbourne, Vic, Australia

[5] Univ Melbourne, Doherty Dept, Peter Doherty Inst Infect & Immun, Melbourne, Vic, Australia

[6] Charles Darwin Univ, Menzies Sch Hlth Res, Darwin, NT, Australia

[7] Univ Melbourne, Sch Comp & Informat Syst, Melbourne Sch Engn, Melbourne, Vic, Australia

[8] Univ Melbourne, Dept Microbiol & Immunol, Peter Doherty Inst Infect & Immun, Melbourne, Vic, Australia

[9] Univ Libre Bruxelles, Mol Bacteriol Lab, Brussels, Belgium

[10] Univ Libre Bruxelles, Acad Children Hosp Queen Fabiola, Dept Pediat, Brussels, Belgium

[11] Univ Melbourne, Ctr Int Child Hlth, Melbourne, Vic, Australia

[12] Griffith Univ, Inst Glyc, Gold Coast Campus, Mt Gravatt, Qld, Australia

[13] Colonial War Mem Hosp, Dept Paediat, Suva, Fiji

[14] Fiji Natl Univ, Coll Med Nursing & Hlth Sci, Suva, Fiji

[15] Fiji Rheumat Heart Dis Control Program, Suva, Fiji

[16] Univ Western Australia, Telethon Kids Inst, Perth, WA, Australia

[17] Univ Melbourne, Melbourne Sch Populat & Global Hlth, Carlton, Vic, Australia

[18] Univ Melbourne, Royal Childrens Hosp Melbourne, Dept Paediat, Parkville, Vic, Australia

来源：

JOURNAL OF INFECTIOUS DISEASES | 2020年 / 221卷 / 09期

基金：

英国医学研究理事会;

关键词：

Streptococcus pyogenes; emm cluster; immunity; skin infection; BETA-HEMOLYTIC STREPTOCOCCI; TISSUE TROPISMS; ACQUISITION; COMMUNITIES; PYOGENES; CHILDREN; THROAT;

D O I：

10.1093/infdis/jiz615

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Group A Streptococcus is a pathogen of global importance, but despite the ubiquity of group A Streptococcus infections, the relationship between infection, colonization, and immunity is still not completely understood. The M protein, encoded by the emm gene, is a major virulence factor and vaccine candidate and forms the basis of a number of classification systems. Longitudinal patterns of emm types collected from 457 Fijian schoolchildren over a 10-month period were analyzed. No evidence of tissue tropism was observed, and there was no apparent selective pressure or constraint of emm types. Patterns of emm type acquisition suggest limited, if any, modification of future infection based on infection history. Where impetigo is the dominant mode of transmission, circulating emm types either may not be constrained by ecological niches or population immunity to the M protein, or they may require several infections over a longer period of time to induce such immunity.We examined longitudinal patterns of emm types in group A Streptococcus samples collected from Fijian schoolchildren. In a setting where impetigo is the dominant mode of transmission, we found no evidence that infection history modifies future infection.

引用

页码：1429 / 1437

页数：9

共 29 条

[1]

Bessen DE, 2017, STREPTOCOCCUS PYOGEN, P97

[2] Molecular Epidemiology, Ecology, and Evolution of Group A Streptococci [J].