Non-allergic asthma as a CFTR-related disorder

被引：16

作者：

Schulz, Angela

Tuemmler, Burkhard

机构：

[1] Hannover Med Sch, Clin Paediat Pneumol Allergol & Neonatol, Hannover, Germany

[2] German Ctr Lung Res, Biomed Res Endstage & Obstruct Lung Dis BREATH, Hannover, Germany

来源：

JOURNAL OF CYSTIC FIBROSIS | 2016年 / 15卷 / 05期

关键词：

Asthma; Bronchiectasis; CFTR; Intestinal current measurement; Nasal transepithelial potential difference; POTENTIAL DIFFERENCE MEASUREMENTS; CYSTIC-FIBROSIS; EXPRESSION; RECOMMENDATIONS; MUTATION;

D O I：

10.1016/j.jcf.2015.10.011

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

Background: CFTR dysfunction can be involved in CBAVD, pancreatitis or bronchiectasis. Methods: Subjects with cystic fibrosis-like disease, equivocal sweat chloride concentrations and no or one disease-causing CFTR mutation were investigated by intestinal current and/or nasal potential difference measurements. Results: A subgroup of female patients who had been diagnosed to suffer from non-allergic asthma showed intermediary chloride concentrations in sweat test, normal chloride secretory responses in the intestine and an abnormal nasal potential difference with Sermet scores in the cystic fibrosis range. Conclusion: Non-allergic asthma is a clinical entity that may be associated with CFTR dysfunction of the respiratory epithelium. (C) 2015 European Cystic Fibrosis Society. Published by Elsevier B.V. All rights reserved.

引用

页码：641 / 644

页数：4

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