A potential role for protein tyrosine phosphatase inhibition by a RuIII-edta complex (edta = ethylenediaminetetraacetate) in its biological activity

被引：31

作者：

Chatterjee, Debabrata ^{[1
]}

Mitra, Anannya ^{[2
]}

Levina, Aviva ^{[2
]}

Lay, Peter A. ^{[2
]}

机构：

[1] Cent Mech Engn Res Inst, Chem Grp, Durgapur 713209, India

[2] Univ Sydney, Sch Chem, Sydney, NSW 2006, Australia

来源：

CHEMICAL COMMUNICATIONS | 2008年 / 25期

关键词：

D O I：

10.1039/b803261k

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

[Ru-III(edta)(OH2/OH)](1-/2-) (edta = ethylenediaminetetraacetate) inhibits protein tyrosine phosphatase (PTP) at physiological pH values in a mechanism that involves binding of the Cys residue of the catalytic domain of the enzyme and similar interactions may be important in the anti-cancer properties of the active forms of many Ru pro-drugs.

引用

页码：2864 / 2866

页数：3

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