The Missing Link between Obesity and Hepatocellular Carcinoma: IL-6-Mediated STAT-3 Activation as a Key Player in Hepatocarcinogenesis

被引:2
|
作者
Beyazit, Yavuz [1 ]
Sayilir, Abdurrahim [1 ]
Suvak, Burak [1 ]
Torun, Serkan [1 ]
机构
[1] Turkiye Yuksek Ihtisas Training & Res Hosp, Dept Gastroenterol, TR-06100 Ankara, Turkey
关键词
TNF EXPRESSION; LIVER-CANCER; IL-6; INFLAMMATION;
D O I
10.1159/000327908
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
引用
收藏
页码:185 / 186
页数:2
相关论文
共 50 条
  • [31] Constitutional activation of IL-6-mediated JAK/STAT pathway through hypermethylation of SOCS-1 in human gastric cancer cell line
    To, KF
    Chan, MWY
    Leung, WK
    Ng, EKW
    Yu, J
    Bai, AHC
    Lo, AWI
    Chu, SH
    Tong, JHM
    Lo, KW
    Sung, JJY
    Chan, FKL
    BRITISH JOURNAL OF CANCER, 2004, 91 (07) : 1335 - 1341
  • [32] LncRNA DANCR Promotes Sorafenib Resistance via Activation of IL-6/STAT3 Signaling in Hepatocellular Carcinoma Cells
    Liu, Yuan
    Chen, Lamei
    Yuan, Huabing
    Guo, Shenghong
    Wu, Gang
    ONCOTARGETS AND THERAPY, 2020, 13 : 1145 - 1157
  • [33] Pyroglutamate Aminopeptidase I Promotes Hepatocellular Carcinoma via IL-6/STAT3 Activation as Revealed by a Specific Biosensor
    Guo, Wu-Yingzheng
    Li, Rong-Rong
    Fu, Yi-Xuan
    Liu, Shi-Yu
    Liu, Guo-Zhen
    Yang, Wen-Chao
    Yang, Guang-Fu
    ANALYTICAL CHEMISTRY, 2021, 93 (39) : 13311 - 13318
  • [34] Activation of NF-κB/IL-6/STAT-3 pathway in esophageal cells by bile acids and low pH
    Dvorakova, K
    Payne, CM
    Chavaria, M
    Landowski, T
    Margelofski, T
    Crowley-Weber, C
    Bernstein, H
    Bernstein, C
    Garewal, H
    GASTROENTEROLOGY, 2004, 126 (04) : A236 - A236
  • [35] Breast cancer promotion by IL-6-mediated cross-talk between human preadipocyte and breast dutal carcinoma in situ
    Kim, Hoe Suk
    Jung, Minji
    Choi, Sul Ki
    Moon, Woo Kyung
    CANCER RESEARCH, 2018, 78 (04)
  • [36] The binding of PKCε and MEG2 to STAT3 regulates IL-6-mediated microglial hyperalgesia during inflammatory pain
    Li, Xiongjuan
    Wang, Junliang
    Liao, Changjian
    Yang, Xinping
    Zhao, Zhao
    Liu, Yuqiang
    Xue, Qingsheng
    Luo, Yan
    Liu, Xuesheng
    Liu, Zhiheng
    FASEB JOURNAL, 2024, 38 (08):
  • [37] MiR-125a-5p Decreases the Sensitivity of Treg cells Toward IL-6-Mediated Conversion by Inhibiting IL-6R and STAT3 Expression
    Dan Li
    Chao Kong
    Andy Tsun
    Chen Chen
    Huihui Song
    Guochao Shi
    Wen Pan
    Dai Dai
    Nan Shen
    Bin Li
    Scientific Reports, 5
  • [38] Atorvastatin-induced senescence of hepatocellular carcinoma is mediated by downregulation of hTERT through the suppression of the IL-6/STAT3 pathway
    Sin-Ting Wang
    Shi-Wei Huang
    Kuang-Ting Liu
    Teng-Yu Lee
    Jeng-Jer Shieh
    Chun-Ying Wu
    Cell Death Discovery, 6
  • [39] CADPE Suppresses Cyclin D1 Expression in Hepatocellular Carcinoma by Blocking IL-6-induced STAT3 Activation
    Won, Cheolhee
    Lee, Chang Seok
    Lee, Jin-Ku
    Kim, Tack-Joong
    Lee, Kwang-Ho
    Yang, Young Mok
    Kim, Yong-Nyun
    Ye, Sang-Kyu
    Chung, Myung-Hee
    ANTICANCER RESEARCH, 2010, 30 (02) : 481 - 488
  • [40] Atorvastatin-induced senescence of hepatocellular carcinoma is mediated by downregulation of hTERT through the suppression of the IL-6/STAT3 pathway
    Wang, Sin-Ting
    Huang, Shi-Wei
    Liu, Kuang-Ting
    Lee, Teng-Yu
    Shieh, Jeng-Jer
    Wu, Chun-Ying
    CELL DEATH DISCOVERY, 2020, 6 (01)