Clinical outcome of relapsing remitting multiple sclerosis among Hong Kong Chinese

Background: Clinical outcome of Chinese relapsing remitting multiple sclerosis (RRMS) patients is uncertain. Aim: To study the long-term clinical outcome of Chinese RRMS patients. Method: RRMS patients with duration of 10 years or longer followed up in our hospital is retrospectively studied. Results: 61 RRMS patients (75% female) were studied. Their mean symptom onset age was 25.9 years and mean duration was 20.6 years (range 10-33); 36% patients had received beta-interferon and 30% azathioprine. Their mean EDSS scores were 3.3 (range 1-7) and 4.7 (range 1-8) at 10 years and latest follow-up (mean duration 20.6 years) respectively. At 10 years, 30% patients had EDSS score <= 2,34% EDSS 2.5-3.5. 20% EDSS 4.0-5.5 and 16% >= 6: 18% developed SPMS. At latest follow-up, 15% patients had EDSS <= 2, 20% EDSS 2.5-3.5, 19% LOSS 4.0-5.5 and 46% >= 6.0; 53% developed SPMS. The median time from symptom onset to EDSS 6 was 22 years. No differences were detected in demographic characteristics, presenting neurological features, number of attacks in first 2 years, neuroradiological findings and disease modifying therapies between patients with LOSS < 6 and >= 6 at ten years. EDSS scores at 10 years and latest follow-up were similar for patients who-had received beta-interferon and those who had not. Conclusion: Hong Kong Chinese RRMS patients may have worse long-term clinical outcome than Caucasian patients. (C) 2011 Elsevier B.V. All rights reserved.