Glutathione-responsive nanoscale MOFs for effective intracellular delivery of the anticancer drug 6-mercaptopurine

被引：32

作者：

Gong, Ming ^{[1
]}

Yang, Jian ^{[1
]}

Li, Yongsheng ^{[1
]}

Gu, Jinlou ^{[1
]}

机构：

[1] East China Univ Sci & Technol, Shanghai Engn Res Ctr Hierarch Nanomat, Sch Mat Sci & Engn, Key Lab Ultrafine Mat,Minist Educ, Shanghai 200237, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2020年 / 56卷 / 47期

基金：

上海市自然科学基金;

关键词：

MESOPOROUS SILICA NANOPARTICLES; METAL-ORGANIC FRAMEWORKS; RELEASE; CHEMISTRY;

D O I：

10.1039/d0cc02872j

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A glutathione-triggered drug delivery system (DDS) based on nanoscale metal-organic frameworks (NMOFs) is developed, which features an intracellular redox-responsive release of an anticancer drug. Compared to normal cells, the current NMOF-based DDS has 3-fold higher cytotoxicity to cancer cells, prefiguring its great potential for selective cancer therapy.

引用

页码：6448 / 6451

页数：4

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