Carbohydrate-based tolylsulfonyl hydrazines: Effective catalysts for Michael addition of indoles to electron-deficient olefins in water

被引：32

作者：

Wu, Peng ^{[1
,2
]}

Wan, Yiqian ^{[2
]}

Cai, Jiwen ^{[1
,2
]}

机构：

[1] Sun Yat Sen Univ, Sch Pharmaceut Sci, Guangzhou 510275, Guangdong, Peoples R China

[2] Sun Yat Sen Univ, Sch Chem & Chem Engn, Guangzhou 510275, Guangdong, Peoples R China

来源：

SYNLETT | 2008年 / 08期

关键词：

carbohydrate-based tolylsulfonyl hydrazines; catalyst; Michael addition of indole; water;

D O I：

10.1055/s-2008-1072735

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Carbohydrate-based tolylsulfonyl hydrazines were used for the first time to catalyze the Michael reaction of indoles to electron-deficient olefins in aqueous media to afford 3-substituted indole derivatives in good to excellent yields at room temperature.

引用

页码：1193 / 1198

页数：6

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