Vitamin D deficiency and insulin resistance in obese African-American adolescents

被引：26

作者：

Nunlee-Bland, Gail ^{[1
]}

Gambhir, Kanwal ^{[1
]}

Abrams, Cynthia ^{[2
]}

Abdul, Mustapha ^{[1
]}

Vahedi, Marjan ^{[1
]}

Odonkor, Wolali ^{[1
]}

机构：

[1] Howard Univ, Div Endocrinol, Washington, DC 20059 USA

[2] Howard Univ, Dept Biochem & Mol Biol, Washington, DC 20059 USA

来源：

JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM | 2011年 / 24卷 / 1-2期

关键词：

African-American; adiponectin; adolescents; insulin resistance; obesity; vitamin D; 25-HYDROXYVITAMIN D; METABOLIC SYNDROME; HYPOVITAMINOSIS-D; CHILDREN; PREVALENCE; ADIPONECTIN; OVERWEIGHT; ADIPOSITY; MARKERS;

D O I：

10.1515/JPEM.2011.107

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objective: The study aim determined if low 25-hydroxy vitamin D levels correlated with low levels of adiponectin and insulin resistance in African American adolescents with body mass index >= 85th%. Patients and methods: Fasting blood levels of adiponectin, 25-hydroxy vitamin D, insulin, glucose, lipid, leptin and glycosylated hemoglobin were measured in a total of 34 (19 study and 15 control) African American adolescents between the ages of 10 and 20 years. Nutritional vitamin D intake and body composition measurements were assessed. Insulin resistance was calculated using the homeostasis model assessment. Results: Adiponectin, fasting insulin, glucose, leptin, triglycerides, HDL, and 25-hydroxy vitamin D levels all reached statistical significance in the group with body mass index >= 85th percentile when compared to the control population. There was no difference in vitamin D intake between the two groups. Conclusions: Low vitamin D levels correlated with low adiponectin levels and obesity and insulin resistance.

引用

页码：29 / 33

页数：5

共 20 条

[1] Hypovitaminosis D in obese children and adolescents: relationship with adiposity, insulin sensitivity, ethnicity, and season [J].