SYNTHESIS AND ANTITUMOR ACTIVITY OF A SERIES OF BENZOFURYL-SUBSTITUTED 1,2,4-TRIAZOLES AND TRIAZOLIN-5-THIONES

被引：0

作者：

Kaldrikyan, M. A. ^{[1
]}

Grigoryan, L. A. ^{[1
]}

Melik-Ogandzhanyan, R. G. ^{[1
]}

Arsenyan, F. G. ^{[1
]}

机构：

[1] Natl Acad Sci Republ Armenia, AL Mndzhoyan Inst Fine Organ Chem, Sci Technol Ctr Organ & Pharmaceut Chem, Erevan, Armenia

来源：

PHARMACEUTICAL CHEMISTRY JOURNAL | 2011年 / 45卷 / 04期

关键词：

Thiosemicarbazide; hydrazide; mercaptotriazole; S-alkylation; N-aminomethylation; triazolin-5-thiones;

D O I：

暂无

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

3-Benzofuryl-4-benzyl(cyclohexyl)-5-mercapto-1,2,4-triazoles were synthesized by cyclization of the corresponding substituted thiosemicarbazides. 5-Mercaptotriazoles were S-alkylated with various alkenyl-substituted benzylhalogenides, chloracetamide, chloroacetic, and alpha-bromopropionic and alpha-bromocaproic acids. The aminomethylation and hydroxymethylation reactions of 3-benzofuryl-4-benzyl(cyclohexyl)-5-mercapto-1,2,4-triazoles were studied. The antitumor activity of the resulting compounds was investigated.

引用

页码：211 / 214

页数：4

共 50 条

[1] Synthesis and antitumor activity of a series of benzofuryl-substituted 1,2,4-triazoles and triazolin-5-thiones
Kaldrikyan M.A.
Grigoryan L.A.
Melik-Ogandzhanyan R.G.
Arsenyan F.G.
Pharmaceutical Chemistry Journal, 2011, 45 (4) : 211 - 214
[2] Synthesis and antitumor activity of some benzofuryl-substituted 1,2,4-triazoles
M. A. Kaldrikyan
L. A. Grigoryan
R. G. Melik-Ogandzhanyan
F. G. Arsenyan
Pharmaceutical Chemistry Journal, 2009, 43 : 242 - 244
[3] Synthesis and antitumor activity of some benzofuryl-substituted 1,2,4-triazoles
Kaldrikyan, M. A.
Grigoryan, L. A.
Melik-Ogandzhanyan, R. G.
Arsenyan, F. G.
PHARMACEUTICAL CHEMISTRY JOURNAL, 2009, 43 (05) : 242 - 244
[4] Synthesis and antitumor activity of 5-methylbenzofuryl-substituted 1,2,4-triazoles and triazoline-5-thiones
M. A. Kaldrikyan
R. G. Melik-Oganjanyan
F. H. Aresnyan
Pharmaceutical Chemistry Journal, 2013, 47 : 191 - 194
[5] Synthesis and antitumor activity of 5-methylbenzofuryl-substituted 1,2,4-triazoles and triazoline-5-thiones
Kaldrikyan, M. A.
Melik-Oganjanyan, R. G.
Aresnyan, F. H.
PHARMACEUTICAL CHEMISTRY JOURNAL, 2013, 47 (04) : 191 - 194
[6] Synthesis and antitumor activity of 3,4,5-substituted 1,2,4-triazoles
T. R. Ovsepyan
R. G. Melik-Ogandzhanyan
G. A. Panosyan
F. G. Arsenyan
B. T. Garibdzhanyan
Pharmaceutical Chemistry Journal, 2009, 43 : 645 - 648
[7] Synthesis and properties of new substituted 1,2,4-triazoles: Potential antitumor agents
Al-Soud, YA
Al-Masoudi, NA
Ferwanah, AERS
BIOORGANIC & MEDICINAL CHEMISTRY, 2003, 11 (08) : 1701 - 1708
[8] SYNTHESIS OF SUBSTITUTED 5-AMINO-1,2,4-TRIAZOLES
EVERS, R
FISCHER, E
JOURNAL FUR PRAKTISCHE CHEMIE, 1985, 327 (04): : 609 - 615
[9] Synthesis and antidepressant activity of di substituted-5-aryl-1,2,4-triazoles
C. Radhika
A. Venkatesham
Manda Sarangapani
Medicinal Chemistry Research, 2012, 21 : 3509 - 3513
[10] Synthesis and antidepressant activity of di substituted-5-aryl-1,2,4-triazoles
Radhika, C.
Venkatesham, A.
Sarangapani, Manda
MEDICINAL CHEMISTRY RESEARCH, 2012, 21 (11) : 3509 - 3513

← 1 2 3 4 5 →