Copper-Catalyzed Intramolecular Hydroalkoxylation of α-(1-Hydroxy-1-alkyl- and -aryl)methylallenoates by a 5-Endo Mode for Preparation of 2-Alkyl- and 2-Aryl-2,5-dihydrofurans

被引：28

作者：

Kim, Sanghyuck ^{[1
]}

Lee, Phil Ho ^{[1
]}

机构：

[1] Kangwon Natl Univ, Dept Chem, Chunchon 200701, South Korea

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2012年 / 77卷 / 01期

基金：

新加坡国家研究基金会;

关键词：

RING-CLOSING METATHESIS; COUPLING-CYCLIZATION REACTION; EFFICIENT SYNTHESIS; 2,3-ALLENOIC ACIDS; 2,5-DIHYDROFURAN DERIVATIVES; CUX2-MEDIATED CYCLIZATION; STEREOSELECTIVE-SYNTHESIS; BETA-HALOBUTENOLIDES; MEDIATED CYCLIZATION; ALLYLIC HALIDES;

D O I：

10.1021/jo2018125

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Ethyl alpha-(1-hydroxy-1-alkyl)methylallenoates and alpha-(1-hydroxy-1-aryl)methylallenoates containing not only electron-donating groups but also an electron-withdrawing group on the aryl group at the alpha-position have been shown to undergo an efficient and selective copper-catalyzed intramolecular hydroalkoxylation to give functionalized 3-ethoxycarbony1-2-alkyl- and -aryl-2,5-dihydrofurans in good to excellent yields through a 5-endo mode.

引用

页码：215 / 220

页数：6

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