Diagnostic Accuracy of Computed Tomography Coronary Angiography According to Pre-Test Probability of Coronary Artery Disease and Severity of Coronary Arterial Calcification The CORE-64 (Coronary Artery Evaluation Using 64-Row Multidetector Computed Tomography Angiography) International Multicenter Study

被引：203

作者：

Arbab-Zadeh, Armin ^{[1
]}

Miller, Julie M. ^{[1
]}

Rochitte, Carlos E. ^{[3
]}

Dewey, Marc ^{[4
]}

Niinuma, Hiroyuki ^{[5
]}

Gottlieb, Ilan ^{[6
]}

Paul, Narinder ^{[7
]}

Clouse, Melvin E. ^{[8
]}

Shapiro, Edward P. ^{[1
]}

Hoe, John ^{[9
]}

Lardo, Albert C. ^{[1
]}

Bush, David E. ^{[1
]}

de Roos, Albert ^{[10
]}

Cox, Christopher ^{[2
]}

Brinker, Jeffrey ^{[1
]}

Lima, Joao A. C. ^{[1
]}

机构：

[1] Johns Hopkins Univ, Div Cardiol, Baltimore, MD 21287 USA

[2] Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Baltimore, MD 21287 USA

[3] Inst Coracao, Div Cardiol, Sao Paulo, Brazil

[4] Charite, Dept Radiol, Berlin, Germany

[5] St Lukes Int Hosp, Div Cardiol, Tokyo, Japan

[6] Univ Fed Rio de Janeiro, Div Cardiol, Rio De Janeiro, Brazil

[7] Toronto Gen Hosp, Dept Radiol, Toronto, ON M5G 2C4, Canada

[8] Beth Israel Deaconess Med Ctr, Dept Radiol, Boston, MA 02215 USA

[9] Mt Elizabeth Hosp, CT Ctr, Singapore, Singapore

[10] Leiden Univ, Dept Radiol, Leiden, Netherlands

来源：

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY | 2012年 / 59卷 / 04期

关键词：

angiography; coronary artery disease; imaging; AMERICAN-HEART-ASSOCIATION; INTERMEDIATE; PERFORMANCE; RADIOLOGY; SCORE;

D O I：

10.1016/j.jacc.2011.06.079

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objectives The purpose of this study was to assess the impact of patient population characteristics on accuracy by computed tomography angiography (CTA) to detect obstructive coronary artery disease (CAD). Background The ability of CTA to exclude obstructive CAD in patients of different pre-test probabilities and in presence of coronary calcification remains uncertain. Methods For the CORE-64 (Coronary Artery Evaluation Using 64-Row Multidetector Computed Tomography Angiography) study, 371 patients underwent CTA and cardiac catheterization for the detection of obstructive CAD, defined as >= 50% luminal stenosis by quantitative coronary angiography (QCA). This analysis includes 80 initially excluded patients with a calcium score >= 600. Area under the receiver-operating characteristic curve (AUC) was used to evaluate CTA diagnostic accuracy compared to QCA in patients according to calcium score and pre-test probability of CAD. Results Analysis of patient-based quantitative CTA accuracy revealed an AUC of 0.93 (95% confidence interval [CI]: 0.90 to 0.95). The AUC remained 0.93 (95% CI: 0.90 to 0.96) after excluding patients with known CAD but decreased to 0.81 (95% CI: 0.71 to 0.89) in patients with calcium score >= 600 (p = 0.077). While AUCs were similar (0.93, 0.92, and 0.93, respectively) for patients with intermediate, high pre-test probability for CAD, and known CAD, negative predictive values were different: 0.90, 0.83, and 0.50, respectively. Negative predictive values decreased from 0.93 to 0.75 for patients with calcium score <100 or >= 100, respectively (p = 0.053). Conclusions Both pre-test probability for CAD and coronary calcium scoring should be considered before using CTA for excluding obstructive CAD. For that purpose, CTA is less effective in patients with calcium score >= 600 and in patients with a high pre-test probability for obstructive CAD. (J Am Coll Cardiol 2012; 59: 379-87) (C) 2012 by the American College of Cardiology Foundation

引用

页码：379 / 387

页数：9

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