An efficient non-ionic surfactant catalyzed multicomponent synthesis of novel benzylamino coumarin derivative via Mannich type reaction in aqueous media

被引：74

作者：

Kumar, Atul ^{[1
]}

Gupta, Maneesh Kumar ^{[1
]}

Kumar, Mukesh ^{[1
]}

机构：

[1] CSIR, Cent Drug Res Inst, Med & Proc Chem Div, Lucknow, Uttar Pradesh, India

来源：

TETRAHEDRON LETTERS | 2011年 / 52卷 / 35期

关键词：

Mannich type reaction; 3-Substituted coumarin; Non-ionic surfactant; Water; Green synthesis; DIVERSITY ORIENTED SYNTHESIS; LEWIS-ACID; KETONES; SYSTEM; AMINES; WATER;

D O I：

10.1016/j.tetlet.2011.06.040

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient non-ionic surfactant catalyzed multicomponent synthesis of novel benzylamino coumarin derivatives has been developed from secondary amines, aromatic aldehyde, and 4-hydroxy coumarin via Mannich type reaction in aqueous media. In this Mannich type reaction, surfactant forms stable colloidal medium to stabilize iminium ion which undergoes nucleophilic addition of 4-hydroxy coumarin to give benzylamino coumarin in very good yields. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：4521 / 4525

页数：5

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