3D scaffolds prepared from acylated chitosan applicable in skin regeneration - synthesis and characterization

被引：6

作者：

Radwan-Praglowska, Julia ^{[1
]}

Piatkowski, Marek ^{[1
]}

Janus, Lukasz ^{[1
]}

Bogdal, Dariusz ^{[1
]}

Matysek, Dalibor ^{[2
]}

Cablik, Vladimir ^{[2
]}

机构：

[1] Cracow Univ Technol, Dept Biotechnol & Phys Chem, Krakow, Poland

[2] Tech Univ Ostrava, Fac Min & Geol, Ostrava, Czech Republic

来源：

INTERNATIONAL JOURNAL OF POLYMER ANALYSIS AND CHARACTERIZATION | 2019年 / 24卷 / 01期

关键词：

Chitosan; biodegradable polymers; biomaterials; 3D scaffolds; microwave radiation; Green Chemistry; IN-VITRO;

D O I：

10.1080/1023666X.2018.1553348

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Nowadays, burn wounds are one of the most emerging problems of medicine. Tissue engineering seems to be a promising solution since it enables new tissue formation on 3 D scaffolds. In this article, a novel strategy for N-acylated chitosan 3 D scaffolds obtainment method is presented. Biomaterials were synthesized according to Green Chemistry principles under microwave-assisted conditions using unsaturated fatty acid chlorides. Ready products were characterized over their physicochemical properties, morphology, mechanical, and biological properties. Performed analyses confirmed obtainment of N-acylated biomaterial with a very porous structure and enhanced durability. Prepared scaffolds were biodegradable and had a positive impact on mouse fibroblasts.

引用

页码：75 / 86

页数：12

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