Decreased expression of NDRG2 is related to poor overall survival in patients with glioma

被引：25

作者：

Li, Wei ^{[1
]}

Chu, Dake ^{[2
]}

Chu, Xiaodan ^{[3
]}

Meng, Fanhua ^{[1
]}

Wei, Dun ^{[4
]}

Li, Haiping ^{[1
]}

Sun, Boqian ^{[1
]}

机构：

[1] Beihua Univ, Dept Neurol, Affiliated Hosp, Beijing 132011, Jilin, Peoples R China

[2] Fourth Mil Med Univ, State Key Lab Canc Biol, Xian 710032, Peoples R China

[3] Beihua Univ, Res Ctr Life Sci, Beijing 132011, Jilin, Peoples R China

[4] Beihua Univ, Dept Neurosurg, Affiliated Hosp, Beijing 132011, Jilin, Peoples R China

来源：

JOURNAL OF CLINICAL NEUROSCIENCE | 2011年 / 18卷 / 11期

关键词：

Glioma; Immunohistochemistry; NDRG2; Survival; PHOTODYNAMIC THERAPY; BRAIN-TUMORS; N-MYC; DOWN-REGULATION; GENE FAMILY; CARCINOMA; DIFFERENTIATION; CANCER;

D O I：

10.1016/j.jocn.2010.12.032

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Members of the NDRG (N-Myc downstream-regulated) gene family have been shown to play a variety of roles in human malignancies. In the present study, we examined the expression of NDRG2 protein in glioma samples of WHO grades I-IV. We also investigated the association between NDRG2 expression and survival. Immunohistochemical analysis was used to measure NDRG2 protein expression in 316 specimens of human glioma and 41 normal control tissues. Survival analysis was performed using the Kaplan-Meier method and Cox's proportional hazards model. We found that NDRG2 expression was reduced in glioma relative to normal tissue, and that NDRG2 expression decreased with increasing glioma grade. Kaplan-Meier analysis showed that patients without NDRG2 expression had a lower survival rate than other patients. Multivariate analysis showed that NDRG2 expression was an independent prognostic factor for overall survival of patients with glioma. The present study provides the first evidence that NDRG2 expression is decreased in gliomas, indicating that NDRG2 may play an inhibitory role during the development of gliomas. NDRG2 expression may also be a significant and independent prognostic indicator for glioma. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：1534 / 1537

页数：4

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