DESIGN AND SYNTHESIS OF BENZOTHIAZOLE SCHIFF BASES OF POTENTIAL ANTITUMOR ACTIVITY

被引：5

作者：

Al-Harthy, Thuraya ^{[1
]}

Abdel-Jalil, Raid ^{[1
]}

Zoghaib, Wajdi ^{[1
]}

Pflueger, Maren ^{[2
]}

Hofmann, Elisabeth ^{[2
]}

Hundsberger, Harald ^{[2
]}

机构：

[1] Sultan Qaboos Univ, Coll Sci, Dept Chem, Muscat, Oman

[2] Krems Univ Appl Sci Krems, IMC Fachhsch, Piaristengasse 1, A-3500 Krems, Austria

来源：

HETEROCYCLES | 2016年 / 92卷 / 07期

关键词：

BIOLOGICAL EVALUATION; CRYSTAL-STRUCTURE; IN-VITRO; DERIVATIVES; AGENTS; INHIBITORS; SCAFFOLD; ANALOGS;

D O I：

10.3987/COM-16-13471

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

In an attempt to develop a new class of selective antitumor agents, a novel series of benzothiazole derivatives was prepared via the condensation of 5-fluoro-6-(4-methylpip erazin-1-yl)benzo[d]thiazol-2-amine with aromatic aldehydes. The preliminary bioassay reveals that (4-fluorobenzylidene)-[5-fluoro-6-(4-methylpiperazin-1-yl)-benzothiazol-2-yl]-amine show specific anticancer cytotoxicity.

引用

页码：1282 / 1292

页数：11

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