Exploring the relationship between cocrystal stability and symmetry:: is Wallach's rule applicable to multi-component solids?

被引：74

作者：

Friscic, Tomislav ^{[1
]}

Fabian, Laszlo ^{[2
]}

Burley, Jonathan C. ^{[3
]}

Reid, David G.

Duer, Melinda J.

Jones, William ^{[1
]}

机构：

[1] Univ Cambridge, Dept Chem, Pfizer Inst Pharmaceut Mat Sci, Cambridge CB2 1EW, England

[2] Cambridge Crystallog Data Ctr, Cambridge CB2 1EZ, England

[3] Univ Nottingham, Sch Pharm, Nottingham NG7 2RD, England

来源：

CHEMICAL COMMUNICATIONS | 2008年 / 14期

关键词：

D O I：

10.1039/b717532a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Comparison of structure and hydration stability of pairs of chiral and racemic binary cocrystals indicates that the racemic solid is more stable than the chiral one; we illustrate that this difference might arise from intermolecular (crystal packing) factors in one case, while intramolecular (molecular conformation) factors are more significant in the other.

引用

页码：1644 / 1646

页数：3

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