Preservation of Retinal Function Through Synaptic Stabilization in Alzheimer's Disease Model Mouse Retina by Lycium Barbarum Extracts

被引:9
作者
Liu, Jinfeng [1 ]
Baum, Larry [2 ,3 ]
Yu, Shasha [1 ,4 ]
Lin, Youhong [1 ]
Xiong, Guoying [1 ]
Chang, Raymond Chuen-Chung [3 ,5 ]
So, Kwok Fai [1 ,3 ,6 ,7 ]
Chiu, Kin [1 ,3 ,6 ]
机构
[1] Univ Hong Kong, LKS Fac Med, Dept Ophthalmol, Pokfulam, Hong Kong, Peoples R China
[2] Univ Hong Kong, LKS Fac Med, Dept Psychiat, Pokfulam, Hong Kong, Peoples R China
[3] Univ Hong Kong, State Key Lab Brain & Cognit Sci, Pokfulam, Hong Kong, Peoples R China
[4] Tianjin Med Univ, Nankai Univ, Tianjin Key Lab Ophthalmol & Visual Sci,Eye Hosp, Tianjin Eye Hosp,Clin Coll Ophthalmol,Tianjin Eye, Tianjin, Peoples R China
[5] Univ Hong Kong, Sch Biomed Sci, Lab Neurodegenerat Dis, Pokfulam, Hong Kong, Peoples R China
[6] Univ Hong Kong, Dept Psychol, Pokfulam, Hong Kong, Peoples R China
[7] Jinan Univ, Guangdong Hongkong Macau Inst CNS Regenerat, Guangzhou, Peoples R China
来源
FRONTIERS IN AGING NEUROSCIENCE | 2022年 / 13卷
关键词
Alzheimer's disease; retina; synapse; Lycium barbarum; 8-OHG; calpain-2; calpain-5; PROTEIN-KINASE; A-BETA; PATHOLOGY; STRESS;
D O I
10.3389/fnagi.2021.788798
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 ; 0303 ; 100203 ;
摘要
In Alzheimer's disease (AD), amyloid beta deposition-induced hippocampal synaptic dysfunction generally begins prior to neuronal degeneration and memory impairment. Lycium barbarum extracts (LBE) have been demonstrated to be neuroprotective in various animal models of neurodegeneration. In this study, we aimed to investigate the effects of LBE on the synapse loss in AD through the avenue of the retina in a triple transgenic mouse model of AD (3xTg-AD). We fed 3xTg-AD mice with low (200 mg/kg) or high (2 g/kg) dose hydrophilic LBE daily for 2 months from the starting age of 4- or 6-month-old. For those started at 6 month age, at 1 month (though not 2 months) after starting treatment, mice given high dose LBE showed a significant increase of a wave and b wave in scotopic ERG. After 2 months of treatment with high dose LBE, calpain-2, calpain-5, and the oxidative RNA marker 8-OHG were downregulated, and presynaptic densities in the inner plexiform layer but not the outer plexiform layer of the retina were significantly increased, suggesting the presynaptic structure of retina was preserved. Our results indicate that LBE feeding may preserve synapse stability in the retina of 3xTg-AD mice, probably by decreasing both oxidative stress and intracellular calcium influx. Thus, LBE might have potential as a neuroprotectant for AD through synapse preservation.
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页数:11
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