Diphenylprolinol methyl ether: A highly enantioselective catalyst for Michael addition of aldehydes to simple enones

被引：225
作者：
Chi, YG [1 ]
Gellman, SH [1 ]
机构：
[1] Univ Wisconsin, Dept Chem, Madison, WI 53706 USA
来源：
ORGANIC LETTERS | 2005年 / 7卷 / 19期
关键词：
D O I：
10.1021/ol0517729
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Diphenylprolinol methyl ether catalyzes intermolecular Michael addition of simple aldehydes to relatively nonactivated enones with the highest enantioselectivities reported to date (95-99% ee) and significantly lower catalyst loadings than have been,typical in this arena.
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页码：4253 / 4256
页数：4
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