New phloroglucinol derivatives with protein tyrosine phosphatase 1B (PTP1B) inhibitory activities from Syzygium austroyunnanense

被引：16

作者：

Xu, Shao-Hua ^{[1
]}

Xu, Wen ^{[1
]}

Wang, Li ^{[1
,2
]}

Hu, Yi-Kao ^{[1
]}

Liu, Jin-Ping ^{[1
]}

Zhao, Yan ^{[1
]}

Li, Meng-Jia ^{[1
]}

Li, Feng ^{[1
]}

Huang, Sheng-Xiong ^{[2
]}

Zhao, Yong ^{[1
]}

机构：

[1] Yunnan Normal Univ, Coll Chem & Chem Engn, Kunming 650500, Yunnan, Peoples R China

[2] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China

来源：

FITOTERAPIA | 2018年 / 131卷

基金：

中国国家自然科学基金;

关键词：

Syzygium austroyunnanense; Myrtaceae; Phloroglucinol derivatives; Structure elucidation; PTP 1B inhibitory activities;

D O I：

10.1016/j.fitote.2018.10.010

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Five new phloroglucinol derivatives (1-5) together with one known analogue (6) were isolated from the leaves of Syzygiwn austroyunnanense which is an edible folk medicine used for the treatment of diabetes. The new structures were elucidated as austroyunones A - E (1-5) by means of the extensive spectroscopic analyses including high-resolution electrospray ionization mass spectrometry (HRESIMS) and ID and 2D nuclear magnetic resonance (NMR). Compounds 4-6 showed obvious protein tyrosine phosphatase 1B (PTP1B) inhibitory activity. This discovery of new phloroglucinols and their bioactivities provided a scientific basis for the application of S. austroyunnanense as an edible and medicinal plant.

引用

页码：141 / 145

页数：5

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