New phloroglucinol derivatives with protein tyrosine phosphatase 1B (PTP1B) inhibitory activities from Syzygium austroyunnanense

被引：16

作者：

Xu, Shao-Hua ^{[1
]}

Xu, Wen ^{[1
]}

Wang, Li ^{[1
,2
]}

Hu, Yi-Kao ^{[1
]}

Liu, Jin-Ping ^{[1
]}

Zhao, Yan ^{[1
]}

Li, Meng-Jia ^{[1
]}

Li, Feng ^{[1
]}

Huang, Sheng-Xiong ^{[2
]}

Zhao, Yong ^{[1
]}

机构：

[1] Yunnan Normal Univ, Coll Chem & Chem Engn, Kunming 650500, Yunnan, Peoples R China

[2] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China

来源：

FITOTERAPIA | 2018年 / 131卷

基金：

中国国家自然科学基金;

关键词：

Syzygium austroyunnanense; Myrtaceae; Phloroglucinol derivatives; Structure elucidation; PTP 1B inhibitory activities;

D O I：

10.1016/j.fitote.2018.10.010

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Five new phloroglucinol derivatives (1-5) together with one known analogue (6) were isolated from the leaves of Syzygiwn austroyunnanense which is an edible folk medicine used for the treatment of diabetes. The new structures were elucidated as austroyunones A - E (1-5) by means of the extensive spectroscopic analyses including high-resolution electrospray ionization mass spectrometry (HRESIMS) and ID and 2D nuclear magnetic resonance (NMR). Compounds 4-6 showed obvious protein tyrosine phosphatase 1B (PTP1B) inhibitory activity. This discovery of new phloroglucinols and their bioactivities provided a scientific basis for the application of S. austroyunnanense as an edible and medicinal plant.

引用

页码：141 / 145

页数：5

共 50 条

[1] Five new phloroglucinol derivatives from Syzygium brachyantherum and their α-glucosidase and PTP1B inhibitory activities
Xu, Wen
Xu, Shao-Hua
Wang, Li
Zang, Zhen
Zhao, Yan
Liu, Jing-Ping
Yang, Jing
Zhao, Yong
NATURAL PRODUCT RESEARCH, 2022, 36 (07) : 1679 - 1685
[2] Protein Tyrosine Phosphatase 1B (PTP1B)-Inhibiting Constituents from the Leaves of Syzygium polyanthum
Saifudin, Azis
Tanaka, Ken
Kadota, Shigetoshi
Tezuka, Yasuhiro
PLANTA MEDICA, 2012, 78 (12) : 1378 - 1381
[3] Inhibitors of protein tyrosine phosphatase 1B (PTP1B)
Taylor, SD
CURRENT TOPICS IN MEDICINAL CHEMISTRY, 2003, 3 (07) : 759 - 782
[4] Protein Tyrosine Phosphatase 1B (PTP1B) and Obesity
Cho, Hyeongjin
OBESITY, 2013, 91 : 405 - 424
[5] Thiazolidinone Derivatives as Competitive Inhibitors of Protein Tyrosine Phosphatase 1B (PTP1B)
Aher, Nilkanth G.
Kafle, Bhooshan
Cho, Hyeongjin
BULLETIN OF THE KOREAN CHEMICAL SOCIETY, 2013, 34 (04) : 1275 - 1277
[6] Phloroglucinol Derivatives with Protein Tyrosine Phosphatase 1B Inhibitory Activities from Eugenia jambolana Seeds
Liu, Feifei
Yuan, Tao
Liu, Wei
Ma, Hang
Seeram, Navindra P.
Li, Yuanyuan
Xu, Li
Mu, Yu
Huang, Xueshi
Li, Liya
JOURNAL OF NATURAL PRODUCTS, 2017, 80 (02): : 544 - 550
[7] New Prenylated Flavanones from Erythrina abyssinica with Protein Tyrosine Phosphatase 1B (PTP1B) Inhibitory Activity
Cui, Long
Lee, Hyun Sun
Ndinteh, Derek Tantoh
Mbafor, Joseph Tanyi
Kim, Young Ho
Le, Thi Van Thu
Nguyen, Phi Hung
Oh, Won Keun
PLANTA MEDICA, 2010, 76 (07) : 713 - 718
[8] New 5-deoxyflavonoids and their inhibitory effects on protein tyrosine phosphatase 1B (PTP1B) activity
Phi Hung Nguyen
Dao, Trong Tuan
Kim, Jayeon
Phong, Do Tuan
Ndinteh, Derek Tantoh
Mbafor, Joseph Tanyi
Oh, Won Keun
BIOORGANIC & MEDICINAL CHEMISTRY, 2011, 19 (11) : 3378 - 3383
[9] Synthesis of (Glycopyranosyl-triazolyl)-purines and Their Inhibitory Activities against Protein Tyrosine Phosphatase 1B (PTP1B)
Luo, Lei
He, Xiao-Peng
Shen, Qiang
Li, Jing-Ya
Shi, Xiao-Xin
Xie, Juan
Li, Jia
Chen, Guo-Rong
CHEMISTRY & BIODIVERSITY, 2011, 8 (11) : 2035 - 2044
[10] Protein tyrosine phosphatase 1B (PTP1B) and α-glucosidase inhibitory activities of Schisandra chinensis (Turcz.) Baill
Fang, Linlin
Cao, Jiaqing
Duan, Lili
Tang, Yun
Zhao, Yuqing
JOURNAL OF FUNCTIONAL FOODS, 2014, 9 : 264 - 270

← 1 2 3 4 5 →