Ratio of Spleen Diameter to Red Blood Cell Distribution Width A Novel Indicator for Celiac Disease

被引:13
作者
Balaban, Daniel Vasile [1 ,2 ]
Popp, Alina [2 ,3 ,4 ]
Lungu, Andrei Marian [1 ]
Costache, Raluca Simona [1 ,2 ]
Anca, Ioana Alina [2 ,3 ]
Jinga, Mariana [1 ,2 ]
机构
[1] Dr Carol Davila Cent Mil Emergency Univ Hosp, Bucharest, Romania
[2] Carol Davila Univ Med & Pharm, Bucharest, Romania
[3] Alfred Rusescu Inst Mother & Child Care, Bucharest, Romania
[4] Univ Tampere, Tampere Ctr Child Hlth Res, FIN-33101 Tampere, Finland
关键词
GUIDELINES; MANAGEMENT; GASTROENTEROLOGY; PREVALENCE; DIAGNOSIS; ATROPHY;
D O I
10.1097/MD.0000000000000726
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Celiac disease (CD) is currently considerably underdiagnosed, setting the need for developing tools to select patients with probability of CD, who warrant further testing. Red blood cell distribution width (RDW) has been shown in previous studies to be a sensitive predictor for CD, but it lacks specificity. Splenic hypotrophy is also noted frequently in celiac patients. Our aim was to evaluate if spleen diameter to RDW ratio can be used as an indicator for CD. We evaluated 15 newly diagnosed CD patients, 52 patients with inflammatory bowel disease, and 35 patients with irritable bowel syndrome (IBS). We evaluated the differences in spleen diameter, RDW, and their ratio among the four groups. Two-thirds of the CD patients had elevated RDW, compared to 9% in the IBS group. A small spleen was seen in 80% of the celiacs, compared to 21.9% in the ulcerative colitis group, 10% in the Crohn disease group, and 9% in the IBS group. A spleen diameter to RDW ratio under 6 had a sensitivity of 73.3% and specificity of 88.5% in predicting CD, with an AUROC of 0.737. Spleen diameter to RDW ratio is a simple, widely available score, which can be used to select adult patients with probability of CD.
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页数:4
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