SPR Biosensor Based on Polymer Multi-Mode Optical Waveguide and Nanoparticle Signal Enhancement

被引：54

作者：

Walter, Johanna-Gabriela ^{[1
]}

Eilers, Alina ^{[1
]}

Alwis, Lourdes Shanika Malindi ^{[2
]}

Roth, Bernhard Wilhelm ^{[3
,4
]}

Bremer, Kort ^{[4
]}

机构：

[1] Leibniz Univ Hannover, Inst Tech Chem, D-30167 Hannover, Germany

[2] Edinburgh Napier Univ, Sch Engn & Built Environm, Edinburgh EH10 5DT, Midlothian, Scotland

[3] Cluster Excellence PhoenixD Photon Opt & Engn Inn, D-30167 Hannover, Germany

[4] Leibniz Univ Hannover, Hannover Ctr Opt Technol, D-30167 Hannover, Germany

来源：

SENSORS | 2020年 / 20卷 / 10期

关键词：

surface plasmon resonance (SPR); sensor; planar-optical; multi-mode; waveguide; biosensor; aptamer; gold-nanoparticle; lab-on-a-chip; SURFACE-PLASMON-RESONANCE; C-REACTIVE PROTEIN; GOLD NANOPARTICLES; SENSOR; FABRICATION; SYSTEM; FUTURE; LIMIT;

D O I：

10.3390/s20102889

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

We present a surface plasmon resonance (SPR) biosensor that is based on a planar-optical multi-mode (MM) polymer waveguide structure applied for the detection of biomolecules in the lower nano-molar (nM) range. The basic sensor shows a sensitivity of 608.6 nm/RIU when exposed to refractive index changes with a measurement resolution of 4.3 x 10(-3) RIU. By combining the SPR sensor with an aptamer-functionalized, gold-nanoparticle (AuNP)-enhanced sandwich assay, the detection of C-reactive protein (CRP) in a buffer solution was achieved with a response of 0.118 nm/nM. Due to the multi-mode polymer waveguide structure and the simple concept, the reported biosensor is well suited for low-cost disposable lab-on-a-chip applications and can be used with rather simple and economic devices. In particular, the sensor offers the potential for fast and multiplexed detection of several biomarkers on a single integrated platform.

引用

页数：11

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