Catalytic asymmetric acyl halide-aldehyde cyclocondensation reactions of substituted ketenes

被引：73

作者：

Nelson, SG ^{[1
]}

Zhu, C ^{[1
]}

Shen, XQ ^{[1
]}

机构：

[1] Univ Pittsburgh, Dept Chem, Pittsburgh, PA 15260 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2004年 / 126卷 / 01期

关键词：

D O I：

10.1021/ja0391208

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Catalytic asymmetric acyl halide-aldehyde cyclocondensation (AAC) reactions of alkyl-substituted ketenes with structurally diverse aldehydes provide cis-disubstituted β-lactones with high enantioselectivity. The AAC reactions utilize a novel Al(III)-triamine catalyst in which the metal′s dynamic coordination geometry leads to a highly selective catalyst complex. These AAC reactions represent a functional solution to highly enantioselective substituted ester enolate aldol additions. Copyright © 2004 American Chemical Society.

引用

页码：14 / 15

页数：2

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