Dithiane- and trithiane-based photolabile scaffolds for molecular recognition

被引：24

作者：

Mitkin, OD ^{[1
]}

Kurchan, AN ^{[1
]}

Wan, YQ ^{[1
]}

Schiwal, BF ^{[1
]}

Kutateladze, AG ^{[1
]}

机构：

[1] Univ Denver, Dept Chem & Biochem, Denver, CO 80208 USA

来源：

ORGANIC LETTERS | 2001年 / 3卷 / 12期

关键词：

D O I：

10.1021/ol015933u

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] A modular synthetic approach to novel dithiane and trithiane-based photolabile molecular hosts equipped with elements of molecular recognition is developed. The approach provides ready access to a family of amino-derivatized photocleavable molecular systems capable of hydrogen-bonding-based recognition of biologically relevant molecules, e,g,, ureas, barbiturates etc. These systems undergo efficient photofragmentation in the presence of external (e.g., benzophenone) or internal (e,g,, nitropyridine) electron-transfer sensitizers.

引用

页码：1841 / 1844

页数：4

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