Polymeric Scaffolds for Dental, Oral, and Craniofacial Regenerative Medicine

被引：94

作者：

Wu, David T. ^{[1
,2
,3
,4
]}

Munguia-Lopez, Jose G. ^{[1
,5
]}

Cho, Ye Won ^{[2
]}

Ma, Xiaolu ^{[1
]}

Song, Vivian ^{[1
]}

Zhu, Zhiyue ^{[5
]}

Tran, Simon D. ^{[1
]}

机构：

[1] McGill Univ, Fac Dent, Craniofacial Stem Cells & Tissue Engn Lab, Montreal, PQ H3A 0C7, Canada

[2] Harvard Univ, Harvard Sch Dent Med, Dept Oral Med Infect & Immun, Boston, MA 02115 USA

[3] Harvard Univ, Harvard John A Paulson Sch Engn & Appl Sci, Cambridge, MA 02138 USA

[4] Harvard Univ, Wyss Inst Biol Inspired Engn, Boston, MA 02115 USA

[5] McGill Univ, Fac Engn, Dept Bioengn, Montreal, PQ H3A 0E9, Canada

来源：

MOLECULES | 2021年 / 26卷 / 22期

基金：

加拿大自然科学与工程研究理事会;

关键词：

polymers; polymeric scaffolds; tissue engineering; regenerative medicine; bone regeneration; sinus augmentation; periodontal regeneration; pulp regeneration; whole tooth regeneration; salivary gland regeneration; SUBEPITHELIAL CONNECTIVE-TISSUE; VERTICAL RIDGE AUGMENTATION; ACELLULAR DERMAL MATRIX; MESENCHYMAL STEM-CELLS; PLATELET-RICH FIBRIN; OSTEOGENIC DIFFERENTIATION; CHITOSAN HYDROGELS; ROOT COVERAGE; POLY(LACTIC-CO-GLYCOLIC ACID); PERIODONTAL REGENERATION;

D O I：

10.3390/molecules26227043

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Dental, oral, and craniofacial (DOC) regenerative medicine aims to repair or regenerate DOC tissues including teeth, dental pulp, periodontal tissues, salivary gland, temporomandibular joint (TMJ), hard (bone, cartilage), and soft (muscle, nerve, skin) tissues of the craniofacial complex. Polymeric materials have a broad range of applications in biomedical engineering and regenerative medicine functioning as tissue engineering scaffolds, carriers for cell-based therapies, and biomedical devices for delivery of drugs and biologics. The focus of this review is to discuss the properties and clinical indications of polymeric scaffold materials and extracellular matrix technologies for DOC regenerative medicine. More specifically, this review outlines the key properties, advantages and drawbacks of natural polymers including alginate, cellulose, chitosan, silk, collagen, gelatin, fibrin, laminin, decellularized extracellular matrix, and hyaluronic acid, as well as synthetic polymers including polylactic acid (PLA), polyglycolic acid (PGA), polycaprolactone (PCL), poly (ethylene glycol) (PEG), and Zwitterionic polymers. This review highlights key clinical applications of polymeric scaffolding materials to repair and/or regenerate various DOC tissues. Particularly, polymeric materials used in clinical procedures are discussed including alveolar ridge preservation, vertical and horizontal ridge augmentation, maxillary sinus augmentation, TMJ reconstruction, periodontal regeneration, periodontal/peri-implant plastic surgery, regenerative endodontics. In addition, polymeric scaffolds application in whole tooth and salivary gland regeneration are discussed.

引用

页数：27

共 167 条

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