Management of Gastrointestinal Stromal Tumors

被引：14

作者：

von Mehren, Margaret ^{[1
]}

机构：

[1] Fox Chase Canc Ctr, Dept Hematol Oncol, C-218,333 Coltman Ave, Philadelphia, PA 19111 USA

来源：

SURGICAL CLINICS OF NORTH AMERICA | 2016年 / 96卷 / 05期

关键词：

GIST; KIT; PDGFRA; SDH-deficient GIST; Tyrosine kinase inhibitors; Adjuvant therapy; Neoadjuvant therapy; Metastasectomy; TYROSINE-KINASE INHIBITOR; SOFT-TISSUE SARCOMAS; PHASE-II TRIAL; IMATINIB MESYLATE; SUCCINATE-DEHYDROGENASE; EXTRAADRENAL PARAGANGLIOMA; LAPAROSCOPIC RESECTION; ACTIVATING MUTATIONS; PULMONARY CHONDROMA; MONOCLONAL-ANTIBODY;

D O I：

10.1016/j.suc.2016.05.011

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

Gastrointestinal stromal tumors had the reputation for poor outcomes because of their lack of response to nonsurgical interventions. The discovery of gain-of-function mutations involving receptor tyrosine kinase growth factor receptors altered the biological understanding and management. Beginning in 2000, management of these tumors has changed dramatically because of the availability of tyrosine kinase inhibitors. The role of surgery continues to be refined. This article reviews how surgery and systemic therapy are being used, incorporating definitions of risk. Decisions on how to treat a patient is based on the risk of progression, pathologic characteristics, and tumor location.

引用

页码：1059 / +

页数：18

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