Peptide-based semiconducting polymer nanoparticles for osteosarcoma-targeted NIR-II fluorescence/NIR-I photoacoustic dual-model imaging and photothermal/photodynamic therapies

被引：43
作者：
Yuan, Ying [1 ]
Diao, Shanchao [2 ,3 ]
Ni, Xiaoyue [2 ,3 ]
Zhang, Dong [1 ]
Yi, Wanrong [1 ]
Jian, Chao [1 ]
Hu, Xiang [1 ]
Li, Daifeng [4 ]
Yu, Aixi [1 ]
Zhou, Wen [2 ,3 ]
Fan, Quli [2 ,3 ]
机构：
[1] Wuhan Univ, Zhongnan Hosp, Dept Orthoped Trauma & Microsurg, Wuhan 430071, Peoples R China
[2] Nanjing Univ Posts & Telecommun, State Key Lab Organ Elect & Informat Displays, Nanjing 210023, Peoples R China
[3] Nanjing Univ Posts & Telecommun, Inst Adv Mat IAM, Nanjing 210023, Peoples R China
[4] Zhengzhou Univ, Affiliated Hosp 1, Henan Key Lab Funct Magnet Resonance Imaging & Mo, Dept Magnet Resonance Imaging, Zhengzhou 450052, Peoples R China
来源：
JOURNAL OF NANOBIOTECHNOLOGY | 2022年 / 20卷 / 01期
关键词：
Dual-modal imaging; Photothermal therapy; Photodynamic therapy; Osteosarcoma-targeted; CHEMOTHERAPY; TRANSCYTOSIS; BIOLOGY; PATHWAY; PROBES;
D O I：
10.1186/s12951-022-01249-4
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Background: The overall survival rate of osteosarcoma (OS) patients has not been improved for 30 years, and the diagnosis and treatment of OS is still a critical issue. To improve OS treatment and prognosis, novel kinds of theranostic modalities are required. Molecular optical imaging and phototherapy, including photothermal therapy (PTT) and photodynamic therapy (PDT), are promising strategies for cancer theranostics that exhibit high imaging sensitivity as well as favorable therapeutic efficacy with minimal side effect. In this study, semiconducting polymer nanoparticles (SPN-PT) for OS-targeted PTT/PDT are designed and prepared, using a semiconducting polymer (PCPDTBT), providing fluorescent emission in the second near-infrared window (NIR-II, 1000 - 1700 nm) and photoacoustic (PA) signal in the first near-infrared window (NIR-I, 650 - 900 nm), served as the photosensitizer, and a polyethylene glycolylated (PEGylated) peptide PT, providing targeting ability to OS. Results: The results showed that SPN-PT nanoparticles significantly accelerated OS-specific cellular uptake and enhanced therapeutic efficiency of PTT and PDT effects in OS cell lines and xenograft mouse models. SPN-PT carried out significant anti-tumor activities against OS both in vitro and in vivo. Conclusions: Peptide-based semiconducting polymer nanoparticles permit efficient NIR-II fluorescence/NIR-I PA dual-modal imaging and targeted PTT/PDT for OS.
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页数：18
相关论文
共 41 条
[1]   Challenging paradigms in tumour drug delivery [J].
不详 .
NATURE MATERIALS, 2020, 19 (05) :477-477
[2]   Immunotherapy for osteosarcoma: Fundamental mechanism, rationale, and recent breakthroughs [J].
Chen, Chenglong ;
Xie, Lu ;
Ren, Tingting ;
Huang, Yi ;
Xu, Jie ;
Guo, Wei .
CANCER LETTERS, 2021, 500 :1-10
[3]   Treatment of osteosarcoma at first recurrence after contemporary therapy - The Memorial Sloan-Kettering Cancer Center Experience [J].
Chou, AJ ;
Merola, PR ;
Wexler, LH ;
Gorlick, RG ;
Vyas, YM ;
Healey, JH ;
LaQuaglia, MP ;
Huvos, AG ;
Meyers, PA .
CANCER, 2005, 104 (10) :2214-2221
[4]   A nanoparticle's pathway into tumours [J].
de Lazaro, Irene ;
Mooney, David J. .
NATURE MATERIALS, 2020, 19 (05) :486-487
[5]   Phage Display in Molecular Imaging and Diagnosis of Cancer [J].
Deutscher, Susan L. .
CHEMICAL REVIEWS, 2010, 110 (05) :3196-3211
[6]   Photoacoustic Imaging: Contrast Agents and Their Biomedical Applications [J].
Fu, Qinrui ;
Zhu, Rong ;
Song, Jibin ;
Yang, Huanghao ;
Chen, Xiaoyuan .
ADVANCED MATERIALS, 2019, 31 (06)
[7]   Clonal dynamics in osteosarcoma defined by RGB marking [J].
Gambera, Stefano ;
Abarrategi, Ander ;
Gonzalez-Camacho, Fernando ;
Morales-Molina, Alvaro ;
Roma, Josep ;
Alfranca, Arantzazu ;
Garcia-Castro, Javier .
NATURE COMMUNICATIONS, 2018, 9
[8]   Germline and somatic genetics of osteosarcoma - connecting aetiology, biology and therapy [J].
Gianferante, D. Matthew ;
Mirabello, Lisa ;
Savage, Sharon A. .
NATURE REVIEWS ENDOCRINOLOGY, 2017, 13 (08) :480-491
[9]   Dual imaging-guided photothermal/photodynamic therapy using micelles [J].
Guo, Miao ;
Mao, Huajian ;
Li, Yanli ;
Zhu, Aijun ;
He, Hui ;
Yang, Hong ;
Wang, Yangyun ;
Tian, Xin ;
Ge, Cuicui ;
Peng, Qiaoli ;
Wang, Xianyong ;
Yang, Xiangliang ;
Chen, Xiaoyuan ;
Liu, Gang ;
Chen, Huabing .
BIOMATERIALS, 2014, 35 (16) :4656-4666
[10]   Light-Triggered Theranostics Based on Photosensitizer-Conjugated Carbon Dots for Simultaneous Enhanced-Fluorescence Imaging and Photodynamic Therapy [J].
Huang, Peng ;
Lin, Jing ;
Wang, Xiansong ;
Wang, Zhe ;
Zhang, Chunlei ;
He, Meng ;
Wang, Kan ;
Chen, Feng ;
Li, Zhiming ;
Shen, Guangxia ;
Cui, Daxiang ;
Chen, Xiaoyuan .
ADVANCED MATERIALS, 2012, 24 (37) :5104-5110
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