Effects of Depression, Anxiety, Stigma, and Disclosure on Health-Related Quality of Life among Chronic Hepatitis B Patients in Dalian, China

被引:21
作者
Li, Ge [1 ]
Wang, Gongchen [2 ]
Hsu, Fang-Chi [3 ]
Xu, Jianzhao [4 ]
Pei, Xia [2 ]
Zhao, Bo [2 ]
Shetty, Avinash [5 ]
机构
[1] Wake Forest Univ, Bowman Gray Sch Med, Dept Precis Med, Winston Salem, NC 27157 USA
[2] Dalian Sixth People Hosp, Dept Infect Dis, Dalian, Liaoning, Peoples R China
[3] Wake Forest Sch Med, Div Publ Hlth, Dept Biostat & Data Sci, Winston Salem, NC 27101 USA
[4] Wake Forest Univ, Bowman Gray Sch Med, Dept Biochem, Winston Salem, NC 27103 USA
[5] Wake Forest Sch Med, Off Global Hlth, Dept Pediat Infect Dis, Winston Salem, NC 27101 USA
关键词
KNOWLEDGE; DISCRIMINATION; INVENTORY; CARRIERS;
D O I
10.4269/ajtmh.19-0007
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
Chronic hepatitis B virus (HBV) infection is a major public health problem in China. We evaluated the impact of psychosocial factors (stigma, disclosure, depression, and anxiety) on health-related quality of life (HRQoL) among people living with chronic HBV infection (CHB) in the city of Dalian, Liaoning Province, China. In this hospital-based cross-sectional study, 401 patients living with chronic HBV infection were enrolled as study participants. Study measures included the Beck depression and anxiety inventory, the WHO Quality of Life (WHOQOL-BREF) assessment, the Toronto Chinese HBV Stigma Scale, and disclosure of HBV status to sexual partners. The primary outcome was HRQoL score as measured by the WHOQOL-BREF. A linear regression model was used to examine the association between HRQoL and the potential risk factors including stigma, disclosure, depression, anxiety, and sociodemographic variables. Stigma, disclosure, depression, and anxiety were the covariates of interest. A majority of the participants were females (n = 251, 65.6%), married (81.6%), and had a college or higher degree (32.4%). Depression, anxiety, stigma, and disclosure of HBV infection were associated with low HRQoL in all four domains of the WHOQOL-BREF (physical, psychological, social, and environmental domains) (P < 0.05), when all psychological factors were included in the model separately. Depression was found to be independently associated with low HRQoL in people living with HBV, when all psychological factors were included in the model simultaneously (P < 0.0001). Our data indicate the urgent need for healthcare providers (HCPs) and policy-makers to implement psychological interventions to improve HRQoL among people living with CHB.
引用
收藏
页码:988 / 994
页数:7
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