Graft-versus-host disease after kidney transplantation

被引:10
作者
Kim, Jong Man [1 ]
Kim, Sung Joo [1 ]
Joh, Jae-Won [1 ]
Kwon, Choon Hyuck David [1 ]
Jang, Kee-Taek [2 ]
An, Jungsuk [2 ]
Ki, Chang-Seok [3 ]
Kang, Eun-Suk [3 ]
Shin, Milljae [1 ]
Kim, Bok Nyeo [4 ]
Lee, Suk-Koo [1 ]
机构
[1] Sungkyunkwan Univ, Dept Surg, Samsung Med Ctr, Sch Med, Seoul 135710, South Korea
[2] Sungkyunkwan Univ, Dept Pathol, Samsung Med Ctr, Sch Med, Seoul 135710, South Korea
[3] Sungkyunkwan Univ, Dept Lab Med, Samsung Med Ctr, Sch Med, Seoul 135710, South Korea
[4] Sungkyunkwan Univ, Organ Transplant Ctr, Samsung Med Ctr, Sch Med, Seoul 135710, South Korea
来源
JOURNAL OF THE KOREAN SURGICAL SOCIETY | 2011年 / 80卷
关键词
Graft-versus-host disease; Human leukocyte antigen; Kidney donation; Kidney transplantation; DONOR;
D O I
10.4174/jkss.2011.80.Suppl1.S36
中图分类号
R61 [外科手术学];
学科分类号
摘要
Graft-versus-host disease (GVHD) is a rare complication after kidney transplantation. We describe a 62-year-old female with end-stage renal disease due to hypertension. She received a kidney with 4 mismatched human leukocyte antigen (HLA) out of 6 HLA - A, B, DR from a deceased donor. After the procedure, the patient showed watery diarrhea on postoperative day (POD) 45. An endoscopic biopsy of the colon revealed some apoptotic cells consistent with GVHD. Thrombocytopenia was gradually developed on POD 54. She received steroid pulse therapy, and thrombocytopenia did not progress. However, pneumonia, renal failure, and cardiac failure occurred. She died due to multiple organ failure. We must consider GVHD in renal transplant recipients without homozygous or identical HLA, who had only watery diarrhea without other typical GVHD symptoms such as skin rash and fever, although GVHD is rare in renal transplant recipients.
引用
收藏
页码:S36 / S39
页数:4
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