Whole-body vibration can attenuate the deterioration of bone mass and trabecular bone microstructure in rats with spinal cord injury

被引：22
作者：
Minematsu, A. [1 ]
Nishii, Y. [1 ]
Imagita, H. [1 ]
Takeshita, D. [2 ]
Sakata, S. [3 ]
机构：
[1] Kio Univ, Fac Hlth Sci, Dept Phys Therapy, 4-4-2 Umaminaka, Koryo, Nara 6350832, Japan
[2] Natl Cerebral & Cardiovasc Ctr, Dept Artificial Organs, Osaka, Japan
[3] Nara Med Univ, Dept Physiol, Nara, Japan
来源：
SPINAL CORD | 2016年 / 54卷 / 08期
关键词：
MINERAL DENSITY; BIOMECHANICAL PROPERTIES; METABOLISM; IMMOBILIZATION; OSTEOPOROSIS; FRACTURES; EXERCISE; MODELS; MUSCLE;
D O I：
10.1038/sc.2015.220
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Study design: Experimental, controlled study. Objective: To examine the effects of whole-body vibration (WBV) on bone mass and trabecular bone microstructure (TBMS) during the early stage in juvenile rats with spinal cord injury (SCI). Setting: Studied at the Kio University in Japan. Methods: Thirty-four 8-week-old male Wistar rats were divided into 3 groups: the SCI group, the sham-operation group (SHAM) and the SCI+WBV group. WBV started on the 8th day after SCI. After 1 or 2 weeks of WBV treatment, measurements of tissue mineral density, trabecular bone mineral content (BMC) and parameters of TBMS were obtained by scanning the proximal tibias with x-ray micro-computed tomography. Serum levels of osteocalcin (OC) and of tartrate-resistant acid phosphatase 5b (TRACP 5b) were measured with ELISA. Results: BMC, volume bone mineral density, bone volume (BV), BV fraction (BV/tissue volume) and connectivity density (Conn.D) of TBMS parameters were significantly higher in SCI+WBV rats than in SCI rats after 2-week WBV. The BMC and BV/TV of bone mass index correlated well with Conn.D, suggesting the preservation of Conn.D. induced by WBV. SCI+WBV rats showed a decrease in serum OC after 1-week WBV, but a quick recovery from that after 2-week WBV. There was no difference in serum TRACP 5b among the 3 groups throughout the experimental period. Conclusion: WBV treatment could attenuate the bone deterioration that occurs during the early stage in juvenile rats with SCI. In a clinic, this early WBV intervention may be an effective rehabilitation modality for preventing bone fragility in SCI patients.
引用
收藏
页码：597 / 603
页数：7
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