Risk assessment modelling of fecal shedding caused by extended-spectrum cephalosporin-resistant Escherichia coli transmitted through waste milk fed to dairy pre-weaned calves

被引:8
作者
Awosile, Babafela B. [1 ]
Smith, Ben A. [2 ]
机构
[1] Univ Prince Edward Isl, Atlantic Vet Coll, Dept Hlth Management, Charlottetown, PE C1A 4P3, Canada
[2] Publ Hlth Agcy Canada, Publ Hlth Risk Sci Div, 160 Res Lane, Guelph, ON N1G 5B2, Canada
基金
加拿大自然科学与工程研究理事会;
关键词
quantitative microbial risk assessment; antimicrobial resistance; AMR; Monte Carlo simulation; mathematical model; ANTIMICROBIAL RESISTANCE; EXPERIMENTAL-INFECTION; ANTIBIOTIC-RESIDUES; FARMS; CATTLE; ENGLAND; WALES; PREVALENCE; REPLACER; ANIMALS;
D O I
10.3168/jds.2017-13196
中图分类号
S8 [畜牧、 动物医学、狩猎、蚕、蜂];
学科分类号
0905 ;
摘要
Waste milk feeding is a common practice in dairy operations. Regardless of the benefits of this practice to the dairy farmers, concerns from the potential dissemination of antimicrobial-resistant bacteria through the gut and subsequent shedding by calves into the environment are increasing. In this study, we employed Monte Carlo simulation to assess the risk of shedding extended-spectrum cephalosporin-resistant Escherichia coli (ESC-R E. coli) caused by waste milk feeding in pre-weaned calves using an exponential dose-response model fit to data for E. coli O157:H7 in cattle. Data from pertinent studies were included in our model to predict the risk of shedding. The median (5th and 95th percentiles) for the daily risk of shedding ESC-R E. coli by calves fed only contaminated waste milk was predicted to be 2.9 x 10(-3) (2.1 x 10(-3), 3.7 x 10(-3)), representing a median daily risk of 29 out of 10,000 calves shedding ESC-R E. coli due to exclusive feeding of waste milk containing ESC-R E. coli. This median value was reduced by 94% when accounting for the proportion of waste milk that does not contain ESC-R E. coli. The overall risk of shedding ESC-R E. coli through the pre-weaning period for farms that feed waste milk to calves was 5.7 x 10(-3) (2.4 x 10(-3), 1.1 x 10(-2)), representing 57 out of 10,000 calves. When accounting for the proportion of farms that do not feed waste milk, the pre-weaning period risk was reduced by 23%. By varying the prevalence of ESC-R E. coli in waste milk using values of 3, 1.5, and 1%, the daily risk of shedding decreased by factors of 50, 65, and 82%, respectively, which supports the reduction of contamination or discontinuation of feeding waste milk containing ESC-R E. coli as major mitigation measures to reduce the risk of shedding caused by ingestion of resistant bacteria. It is anticipated that the effects of antimicrobial residues in waste milk, which was not considered herein due to lack of data, would further increase risks. Although waste milk feeding to calves may be economically beneficial to the dairy farmers, there exists the risk of dissemination of ESC-resistant bacteria into the environment.
引用
收藏
页码:9667 / 9673
页数:7
相关论文
共 33 条
[1]   Feeding mastitis milk to organic dairy calves: effect on health and performance during suckling and on udder health at first calving [J].
Abb-Schwedler, Katharina ;
Maeschli, Ariane ;
Boss, Renate ;
Graber, Hans U. ;
Steiner, Adrian ;
Klocke, Peter .
BMC VETERINARY RESEARCH, 2014, 10
[2]  
Alali WQ, 2004, J ANIM SCI, V82, P2148
[3]  
[Anonymous], 2017, EFSA J
[4]   Feeding untreated and pasteurized waste milk and bulk milk to calves: effects on calf performance, health status and antibiotic resistance of faecal bacteria [J].
Aust, V. ;
Knappstein, K. ;
Kunz, H. -J. ;
Kaspar, H. ;
Wallmann, J. ;
Kaske, M. .
JOURNAL OF ANIMAL PHYSIOLOGY AND ANIMAL NUTRITION, 2013, 97 (06) :1091-1103
[5]  
Benham C. L., 1990, BR VET J, V146
[6]   Escherichia coli O157:H7 infection of calves:: infectious dose and direct contact transmission [J].
Besser, TE ;
Richards, BL ;
Rice, DH ;
Hancock, DD .
EPIDEMIOLOGY AND INFECTION, 2001, 127 (03) :555-560
[7]   A survey of dairy calf management practices in Canada that affect animal welfare [J].
Vasseur, E. ;
Borderas, F. ;
Cue, R. I. ;
Lefebvre, D. ;
Pellerin, D. ;
Rushen, J. ;
Wade, K. M. ;
de Passille, A. M. .
JOURNAL OF DAIRY SCIENCE, 2010, 93 (03) :1307-1315
[8]   A longitudinal field trial assesing the impact of feeding waste milk containing antibiotic residues on the prevalence of ESBL-producing Escherichia coli in calves [J].
Brunton, L. A. ;
Reeves, H. E. ;
Snow, L. C. ;
Jones, J. R. .
PREVENTIVE VETERINARY MEDICINE, 2014, 117 (02) :403-412
[9]   A survey of antimicrobial usage on dairy farms and waste milk feeding practices in England and Wales [J].
Brunton, L. A. ;
Duncan, D. ;
Coldham, N. G. ;
Snow, L. C. ;
Jones, J. R. .
VETERINARY RECORD, 2012, 171 (12) :296-U39
[10]  
Call Douglas R., 2008, Animal Health Research Reviews, V9, P159, DOI 10.1017/S1466252308001515